CNR2
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Official Full Name
cannabinoid receptor 2 (macrophage) -
Overview
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008] -
Synonyms
CNR2;cannabinoid receptor 2 (macrophage);CB2;CX5;CB-2;cannabinoid receptor 2;testis-dominant CNR2 isoform CB2
Recombinant Proteins
- Rat
- Zebrafish
- Human
- Mouse
- Zea Mays
- Mus musculus
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&Flag
- GST
- His&Fc&Avi
Involved Pathway
CNR2 involved in several pathways and played different roles in them. We selected most pathways CNR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by GPCR | OXGR1,NMB,OPN1SW1,EMR2,PNOC,XK,GPR55,CRHB,RGS20,ARHGEF18 |
| Signal Transduction | PCSK5,SOX9A,VIP,PDK4,MLN,DNAL4,PDK3,USP9,SPOP,KLHL12 |
| Class A/1 (Rhodopsin-like receptors) | RGR,NMS,GPBAR1,SAA1,GPR31,TAC2,EDN3,NPS,NPB,CCK |
| GPCR ligand binding | RCA2.1,NMU,PRLH,PROKR1,RAMP2,LTB4R,UTS2,CX3CR1,CXCL11.8,CYSLTR1 |
| Neuroactive ligand-receptor interaction | OPRM1,GIPR,HTR6,HCRTR1,RXFP1,GRIA1A,GABRQ,TAAR12F,SSTR1,TAAR11 |
| GPCRs, Class A Rhodopsin-like | CMKLR1,DRD3,GPR27,FPR-RS4,GPR85,APLNR,OPN3,OPN1SW,CX3CR1,GPR75 |
| G alpha (i) signalling events | CHRM4,PMCH,SSTR1,CCL35.1,AGT,OPN1MW2,SSTR2,S1PR5B,HEBP1,S1PR3 |
| GPCR downstream signaling | PROK1,UTS2D,OPN1LW1,ANXA1,TAC2,HCRT,CXCL11.8,ADRA2A,FPR-RS4,RHOL |
Protein Function
CNR2 has several biochemical functions, for example, cannabinoid receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNR2 itself. We selected most functions CNR2 had, and list some proteins which have the same functions with CNR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cannabinoid receptor activity | GPR55,CNR1 |
Interacting Protein
CNR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNR2.
win 55212-2;PSMD2;q81pt2_bacan;mtaD
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References
- Simkins, T; Crawford, RB; et al. Enhanced Humoral Immunity in Mice Lacking CB1 and CB2 Receptors (Cnr1 (-/-) /Cnr2 (-/-) Mice) is not Due to Increased Splenic Noradrenergic Neuronal Activity. JOURNAL OF NEUROIMMUNE PHARMACOLOGY 9:544-557(2014).
- Cecyre, B; Thomas, S; et al. Evaluation of the specificity of antibodies raised against cannabinoid receptor type 2 in the mouse retina. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 387:175-184(2014).
