CNGA3
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Official Full Name
cyclic nucleotide gated channel alpha 3 -
Overview
Cyclic nucleotide-gated cation channel alpha-3 is a protein that in humans is encoded by the CNGA3 gene. -
Synonyms
CNGA3;cyclic nucleotide gated channel alpha 3
Recombinant Proteins
- Human
- Mouse
- Chicken
- Mus musculus
- Bovine
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
CNGA3 involved in several pathways and played different roles in them. We selected most pathways CNGA3 participated on our site, such as Olfactory transduction,Visual signal transduction: Cones,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNGA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Visual signal transduction: Cones | RLN1,GRK7,ARR3,RDH12 |
| cAMP signaling pathway | CALML5,ACOX1,GABBR2,MAPK9,ATP1A4,GRIA1,HCN2,CAMK2B,GNAI3,GRIA4 |
| Olfactory transduction | OR10A5,SLC24A4,OLFR491,GNG13,OR12D2,OLFR186,OLFR494,OLFR5,OR4C12,OLFR1440 |
Protein Function
CNGA3 has several biochemical functions, for example, cGMP binding,intracellular cAMP activated cation channel activity,intracellular cGMP activated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNGA3 itself. We selected most functions CNGA3 had, and list some proteins which have the same functions with CNGA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| intracellular cAMP activated cation channel activity | CNGA1,HCN2,HCN4,CNGA4,CNGA5 |
| cGMP binding | PDE11A,CNGA2,PDE2A,CNGA4,PRKG1A,PDE6G,PDE10A,PDE6H,CNGA1,PRKG2 |
| ligand-gated ion channel activity | ANXA6,CLCA5,CLCA2,CHRNA4,CHRNB2,TRPA1A,GABRB1,ZACN,Chrng,CHRNB4 |
| voltage-gated potassium channel activity | KCNJ11,KCNH1B,KCNA2,KCNB2,KCNAB1A,KCNAB2B,KCNH8,KCNQ1,KCNG4A,KCNV2B |
| intracellular cGMP activated cation channel activity | AQP1,CNGA2,CNGA5,CNGA1,CNGA4 |
Interacting Protein
CNGA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNGA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNGA3.
ARRB1
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References
- Selvakumar, D; Drescher, MJ; et al. CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1. BIOCHEMICAL JOURNAL 443:463-476(2012).
- Chao, YC; Cheng, CJ; et al. Guanylate cyclase-G, expressed in the Grueneberg ganglion olfactory subsystem, is activated by bicarbonate. BIOCHEMICAL JOURNAL 432:267-273(2010).
