CLNS1A
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Official Full Name
chloride channel, nucleotide-sensitive, 1A -
Overview
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. -
Synonyms
CLNS1A;chloride channel, nucleotide-sensitive, 1A;CLCI;methylosome subunit pICln;ICln;nucleotide sensitive 1A;Chloride channel;Chloride channel nucleotide sensitive 1A;Chloride channel regulatory protein;Chloride conductance regulatory protein ICln;Chloride ion current inducer protein;CLNS 1A;CLNS1B;I(Cln);ICLN_HUMAN;Reticulocyte pICln;OTTHUMP00000228612;OTTHUMP00000228613;OTTHUMP00000228614;OTTHUMP00000228843;OTTHUMP00000228845;reticulocyte protein ICln;chloride
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Rabbit
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- N-His&C-Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLNS1A-3743H | Recombinant Human CLNS1A protein, GST-tagged | E.coli | Human | GST | 1-237 aa | |
| CLNS1A-1458R | Recombinant Rat CLNS1A Protein | Mammalian Cells | Rat | His |
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| CLNS1A-1509H | Recombinant Human CLNS1A Protein, GST-tagged | Wheat Germ | Human | GST |
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| CLNS1A-27276TH | Recombinant Human CLNS1A, His-tagged | E.coli | Human | His | 41-237 a.a. |
|
| CLNS1A-360H | Recombinant Human chloride channel, nucleotide-sensitive, 1A, His-tagged | E.coli | Human | His | 1-237 a.a. |
|
| CLNS1A-8993Z | Recombinant Zebrafish CLNS1A | Mammalian Cells | Zebrafish | His |
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| CLNS1A-7437HCL | Recombinant Human CLNS1A 293 Cell Lysate | HEK293 | Human | Non |
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| CLNS1A-1116R | Recombinant Rat CLNS1A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CLNS1A-1116R-B | Recombinant Rat CLNS1A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CLNS1A-1885HF | Recombinant Full Length Human CLNS1A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 237 amino acids |
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| CLNS1A-535R | Recombinant Rabbit CLNS1A protein, His&Myc-tagged | E.coli | Rabbit | N-His&C-Myc | 2-236aa |
|
Involved Pathway
CLNS1A involved in several pathways and played different roles in them. We selected most pathways CLNS1A participated on our site, such as Gene Expression,Metabolism of non-coding RNA,RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLNS1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| snRNP Assembly | PEAK1,SNUPN,DDX20,WDR77 |
| Gene Expression | ARHGEF38,ZNF710,MED16,EIF2S3,CCNC,ZNF324,HELZ2,TACO1,ZNF394,ZNF10 |
| Metabolism of non-coding RNA | SNUPN,DDX20,PRMT5,PEAK1,WDR77 |
| RNA transport | NUP160,NCBP1,EIF4E1B,EIF2B5,SMN,EIF3HA,EEF1A1L2,SEC13,SUMO3B,RPP21 |
Protein Function
CLNS1A has several biochemical functions, for example, poly(A) RNA binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLNS1A itself. We selected most functions CLNS1A had, and list some proteins which have the same functions with CLNS1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | HIST1H4A,SART1,HSPA9,PRPF6,IFI203,DDX56,NUPL2,ZNF346,RBM26,KIF1C |
| protein binding | MPL,NCF4,TMEM231,ACVR1,COMMD5,KCNJ6,ADAM8,CTNND1,TIMM44,KCTD9 |
| protein heterodimerization activity | KCNB2,HER5,POLA1,ALX1,GCA,HIST1H4J,POU5F3,HIST1H2A9,FLOT1,NFYB |
Interacting Protein
CLNS1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLNS1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CLNS1A.
SNRPD1;SNRPD2;SNRPD3
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