CLIC2
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Official Full Name
chloride intracellular channel 2 -
Overview
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue.This gene maps to the candidate region on chromosome X for incontinentia pigmenti. -
Synonyms
CLIC2;chloride intracellular channel 2;chloride intracellular channel protein 2;XAP121;CLIC 2b;CLIC2_HUMAN;CLIC2b;OTTHUMP00000196471;XAP 121;OTTHUMP00000024248
Recombinant Proteins
- Rat
- Human
- Chicken
- Zebrafish
- Rhesus macaque
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
CLIC2 involved in several pathways and played different roles in them. We selected most pathways CLIC2 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLIC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Stimuli-sensing channels | CLCN4-2,TRPM1,TRPM4A,NHEDC1,SGK2,TRPA1A,TTYH3,TRPC4,GSDMA2,ANO10 |
| Ion channel transport | ANO8,TRPC4AP,TCIRG1,ATP13A5,TTYH3,BSND,CLCNKA,BEST1,TRPA1A,CLCN6 |
| Transmembrane transport of small molecules | SLC34A3,SLC13A5A,TTYH3,SLC6A11,FXYD7,RHBG,SGK2,SLC35B3,SLC6A19A,SLC29A1A |
Protein Function
CLIC2 has several biochemical functions, for example, chloride channel activity,glutathione peroxidase activity,NOT glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLIC2 itself. We selected most functions CLIC2 had, and list some proteins which have the same functions with CLIC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PLEKHO1,FHL1,SHARPIN,CD27,ARHGEF2,CTDSP1,PSEN2,APBA3,TGFBR3,SGOL2 |
| voltage-gated ion channel activity | CLCN3,KCNJ1A.4,KCNK16,CYBB,TMEM109,KCNJ1A.5,CLIC5B,CLCNKB,CACNA1C,TRPM5 |
| glutathione peroxidase activity | MGST1,GRX2,MGST3,GSTK1,GSTT1,GPX7,GPX3,PRDX6,MGST2,GPX8 |
| NOT glutathione transferase activity | CLIC5,CLIC1,CLIC3,ALOX5AP |
| chloride channel activity | TTYH3B,GABRA6,GABRG2,SLC26A6L,CFTR,SLC26A11,BEST1,CLIC5B,ANO2,SLC26A2 |
Interacting Protein
CLIC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLIC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLIC2.
FN1
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