Clec7a
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Official Full Name
C-type lectin domain family 7, member A -
Overview
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded;glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a;cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition;receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this;way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms,;have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the;natural killer gene complex region. -
Synonyms
CLEC7A;C-type lectin domain family 7, member A;C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12 , CLECSF12;C-type lectin domain family 7 member A;dectin 1;hDectin 1;Beta GR;BGR;C type calcium dependent carbohydrate recognition domain lectin superfamily member 12;C type lectin domain family 7 member a;CLEC7A protein;Clecsf12;DECTIN 1 receptor;Dectin1;Dendritic cell associated C type lectin 1;Lectin like receptor 1;Putative transmembrane protein dectin 1;dectin-1;OTTHUMP00000164964;OTTHUMP00000164965;OTTHUMP00000164966;OTTHUMP00000233744;OTTHUMP00000233745;OTTHUMP00000233746;OTTHUMP00000233748;OTTHUMP00000233749;beta-glucan receptor;lectin-like receptor 1;DC-associat;CANDF4
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- HEK293
- Mammalian cells
- N-hFc
- Wheat Germ
- Human Cell
- Mammalian Cell
- In Vitro Cell Free System
- His
- GST
- Non
- Fc
- Flag
- mFc
- His&Fc&Avi
Involved Pathway
Clec7a involved in several pathways and played different roles in them. We selected most pathways Clec7a participated on our site, such as Phagosome,Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Clec7a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | SEC22BA,COLEC12,CTSSB.2,SEC61G,SEC22B,MPO,C3A.1,Ctsl,TLR2-1,ACTB |
| Tuberculosis | PMAP-36,RAB5B,TRAF6,SPHK2,CAMK2D,PPP3CB,NFKB1,BAX,NFYA,CASP9 |
Protein Function
Clec7a has several biochemical functions, for example, (1->3)-beta-D-glucan binding,(1->3)-beta-D-glucan receptor activity,MHC protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Clec7a itself. We selected most functions Clec7a had, and list some proteins which have the same functions with Clec7a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| (1->3)-beta-D-glucan binding | PTX3,CD209B |
| protein binding | MKL1,CDC42BPG,TCHP,FKBP3,SMO,PFKFB1,CASK,PIP,RPS10,BLOC1S3 |
| carbohydrate binding | KLRC3,CLEC4M,LY75,ILLR1,CLEC2H,GALNTL6,CD22,LMAN1L,FCN3,PKD1L3 |
| opsonin binding | ITGAM,Itgam&Itgb2 |
| signaling pattern recognition receptor activity | MARCO,TRIM5,TLR2,FCN1,COLEC12,DMBT1 |
| MHC protein binding | TRGV3,MARCH1 |
| metal ion binding | CFI,CYB5D1,RNF148,TRIM109,KLF12A,PGM2L1,HARBI1,HEPHL1A,NMRK2,ATP2C2 |
Interacting Protein
Clec7a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Clec7a here. Most of them are supplied by our site. Hope this information will be useful for your research of Clec7a.
BNIP3L;SYNE4;PTTG1IP;IL1RL1;BNIP3
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