CHRNA7
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Official Full Name
cholinergic receptor, nicotinic, alpha 7 (neuronal) -
Overview
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] -
Synonyms
CHRNA7;cholinergic receptor, nicotinic, alpha 7 (neuronal);NACHRA7;CHRNA7-2;neuronal acetylcholine receptor subunit alpha-7;a7 nicotinic acetylcholine receptor;alpha-7 nicotinic cholinergic receptor subunit;alpha 7 neuronal nicotinic acetylcholine receptor;cholinergic receptor, nicotinic, alpha polypeptide 7;neuronal acetylcholine receptor protein, alpha-7 chain
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
CHRNA7 involved in several pathways and played different roles in them. We selected most pathways CHRNA7 participated on our site, such as Acetylcholine Binding And Downstream Events,Activation of Nicotinic Acetylcholine Receptors,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GRIK5,PRSS1,GRM2,TRY,GRIK4,TSPO,PRLHR2B,LPAR6A,P2RY4,MC1R |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | CHRNA1,CHRNB2,CHRNA2,CHRNA5,CHRNB4,CHRNA3,CHRNA4 |
| Chemical carcinogenesis | GSTA2,CYP3A4,UGT1A2,UGT1A6A,UGT2A2,ALDH3B1,GSTA4,CYP2A6,GSTM6,GSTM5 |
| Neuronal System | SYN2,KCNK16,KCNG1,KCNB1,CHRNA1,CPLX1,KCNN1B,NSFB,SLC1A3A,KCNAB3 |
| Activation of Nicotinic Acetylcholine Receptors | CHRNA3,CHRNA5,CHRNE,CHRNA2,CHRNA1,CHRNA4,CHRNB2,CHRNB4,CHRND |
| Calcium signaling pathway | PDE1A,TNNC1A,AVPR1A,HTR2C,HTR5A,ADCY1B,GNA15.4,ITPR1,CALM3,CACNA1D |
| Cholinergic synapse | CREB3L4,SLC5A7,KCNJ12,FYN,CAMK2B,KCNJ4,GNB4,GNAI2,GNG2,CHRNA3 |
| Acetylcholine Binding And Downstream Events | CHRNE,CHRNA2,CHRNA1,CHRNA4,CHRNB4,CHRNA5,CHRNB2,CHRND,CHRNA3 |
Protein Function
CHRNA7 has several biochemical functions, for example, ATPase binding,acetylcholine binding,acetylcholine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA7 itself. We selected most functions CHRNA7 had, and list some proteins which have the same functions with CHRNA7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetylcholine receptor activity | ANXA9,CHRNB4,CHRNA5,CHRNA3,CHRNA4,CHRNE,CHRNA2,CHRNA6,CHRNB2 |
| acetylcholine binding | CHRNB1,CHRNB3,CHRNA4,CHRNA3,CHRFAM7A,CHRM3,ACHE,CHRNB2 |
| chloride channel regulator activity | SGK3,SGK2B,SLC9A3R1,SGK2A,BSND,SGK1,SGK2 |
| protein homodimerization activity | UGT1A6,NRBP1,AXIN1,VIL1,MTPAP,MAP3K11,CCBL1,NR2F2,GDNFA,ADRA2C |
| toxic substance binding | NEFH,ASS1,H2-AB1,PHAX,EPHX2,Alb,A4GALT,AZU1,DSG1,GUCY2C |
| acetylcholine-gated cation channel activity | CHRNA9 |
| scaffold protein binding | ATP2B4,NLGN4Y,NCK2,CHUK,HOMER1,GRID2,CRIPT,CAV2,KRT15,NLGN3 |
| beta-amyloid binding | APBA3,BCHE,APOE,TGFB2,ITM2C,MAPK8IP2,APBB3,BACE1,NGFR,ACHE |
| acetylcholine-activated cation-selective channel activity | CHRNE,CHRND,CHRNA6,CHRNB1L,CHRNB2,CHRNA5,CHRNA4B,CHRNB4,Chrng,CHRNA3 |
Interacting Protein
CHRNA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA7.
APP;APP;ATXN1
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