CHRNA6
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Official Full Name
cholinergic receptor, nicotinic, alpha 6 -
Overview
This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. -
Synonyms
CHRNA6;cholinergic receptor, nicotinic, alpha 6;cholinergic receptor, nicotinic, alpha polypeptide 6;neuronal acetylcholine receptor subunit alpha-6;Cholinergic receptor nicotinic alpha 6;Cholinergic receptor nicotinic alpha polypeptide 6;CHRNA 6;Neuronal acetylcholine receptor subunit alpha 6;CHNRA6
Recombinant Proteins
- Rat
- Mouse
- Zebrafish
- Human
- Chicken
- Mammalian Cells
- E.coli
- HEK293
- His
- His&Fc&Avi
- His&GST
Involved Pathway
CHRNA6 involved in several pathways and played different roles in them. We selected most pathways CHRNA6 participated on our site, such as Neuroactive ligand-receptor interaction,Cholinergic synapse,Nicotine addiction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cholinergic synapse | CAMK2D,PIK3R2,KCNJ12,GNG8,CAMK4,AKR1C1,PRKACG,GNG12,GNG3,GNG2 |
| Nicotine addiction | GABRA1,GABRA4,GRIN2B,GABRG1,GABRB2,GRIA3,GABRA3,GRIN2C,GABRD,GABRA2 |
| Neuroactive ligand-receptor interaction | GABRQ,MCHR1,APLNR,TACR3,GABRE,PTGER4A,CYSLTR2,GABRG2,CSH2,DRD4-RS |
Protein Function
CHRNA6 has several biochemical functions, for example, contributes_to acetylcholine binding,acetylcholine receptor activity,acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA6 itself. We selected most functions CHRNA6 had, and list some proteins which have the same functions with CHRNA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to acetylcholine binding | CHRNA4,CHRNA4B,CHRNA10,CHRNA3,CHRNA10A,CHRNE,CHRNB3A,CHRNA2,CHRNB3B,CHRNB1 |
| acetylcholine-activated cation-selective channel activity | CHRNB3A,CHRNA4,CHRNB3B,CHRNE,CHRNA10A,CHRNB4,CHRNA2A,CHRNB3,CHRNB1L,CHRNB2 |
| acetylcholine receptor activity | CHRNB2,CHRNA7,CHRNE,CHRNA5,ANXA9,CHRNA3,CHRNA4,CHRNA2,CHRNB4 |
Interacting Protein
CHRNA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA6.
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