CHRNA4
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Official Full Name
cholinergic receptor, nicotinic, alpha 4 -
Overview
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. -
Synonyms
CHRNA4;EBN;BFNC;EBN1;NACHR;NACRA4;NACHRA4;FLJ95812;ENFL1;cholinergic receptor, nicotinic, alpha 4;neuronal acetylcholine receptor subunit alpha-4;OTTHUMP00000031784;cholinergic receptor, nicotinic, alpha polypeptide 4;neuronal nicotinic acetylcholine receptor alpha-4 subunit
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
CHRNA4 involved in several pathways and played different roles in them. We selected most pathways CHRNA4 participated on our site, such as Acetylcholine Binding And Downstream Events,Activation of Nicotinic Acetylcholine Receptors,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Highly sodium permeable acetylcholine nicotinic receptors | CHRNB4,CHRNA3,CHRNB2,CHRND,CHRNE |
| Neuronal System | GABRR2A,KCNS2,KCNK1A,SNAP25A,KCNN1B,GRIP1,KCNJ14,KCNAB3,CHRNA3,RERG |
| Cholinergic synapse | GNAI1,PRKCA,BCL2,PLCB3,GNGT2,SLC5A7,PRKACB,KCNQ2,CAMK4,GNAO1 |
| Neuroactive ligand-receptor interaction | TAAR4,MC5R,CSH1,FSHB,PRLHR,OPRL1,ADRA2DB,TAAR9,HCRTR1,TAAR8C |
| Highly calcium permeable nicotinic acetylcholine receptors | CHRNA1,CHRNA3,CHRNB2,CHRNB4,CHRNA5,CHRNA2 |
| Activation of Nicotinic Acetylcholine Receptors | CHRNB4,CHRNB2,CHRND,CHRNA3,CHRNA1,CHRNA2,CHRNA5,CHRNE,CHRNA7 |
| Acetylcholine Binding And Downstream Events | CHRND,CHRNA1,CHRNB4,CHRNA3,CHRNA7,CHRNA5,CHRNA2,CHRNE,CHRNB2 |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | CHRNA5,CHRNA1,CHRNB2,CHRNB4,CHRNA2,CHRNA3,CHRNA7 |
Protein Function
CHRNA4 has several biochemical functions, for example, contributes_to acetylcholine binding,acetylcholine binding,acetylcholine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA4 itself. We selected most functions CHRNA4 had, and list some proteins which have the same functions with CHRNA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetylcholine binding | CHRNB2,CHRNA7,CHRFAM7A,ACHE,CHRNB1,CHRNB3,CHRNA3,CHRM3 |
| acetylcholine-activated cation-selective channel activity | CHRNB3B,CHRNA10A,CHRNE,CHRNA4B,Chrng,CHRNB3,CHRNA2A,CHRNA6,CHRND,CHRNB4 |
| ligand-gated ion channel activity | TRPA1B,CHRNB4,ANXA6,CHRNA3,GABRB1,CLCA2,TRPA1A,CNGA3,CLCA5,ZACN |
| acetylcholine receptor activity | CHRNB2,CHRNA3,CHRNA5,CHRNA7,CHRNA2,CHRNB4,ANXA9,CHRNE,CHRNA6 |
| contributes_to acetylcholine binding | CHRNB3A,CHRNA3,ZACN,CHRNB1L,CHRNA4B,CHRNB1,CHRNB4,CHRNA1,CHRNA10A,CHRNA10 |
Interacting Protein
CHRNA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA4.
CHRNB2;CSNK2B
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