CFL1
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Official Full Name
cofilin 1 (non-muscle) -
Overview
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004] -
Synonyms
CFL1;cofilin 1 (non-muscle);CFL;HEL-S-15;cofilin-1;p18;18 kDa phosphoprotein;cofilin, non-muscle isoform;epididymis secretory protein Li 15
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- Rhesus macaque
- Candida albicans
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Fc
- His&Strep
- His&Fc&Avi
- Flag
Involved Pathway
CFL1 involved in several pathways and played different roles in them. We selected most pathways CFL1 participated on our site, such as Axon guidance,BDNF signaling pathway,CDC42 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | PCSK6,PLXNC1,EVL,RND1L,DUSP7,NR2F2,SHB,TRIO,RHOB,COL9A1A |
| CXCR4-mediated signaling events | MAPKAP1,GNB2L1,DNM1,BLK,ADRBK1,PAG1,CSK,GNA13,JAK2,CRK |
| Fc gamma R-mediated phagocytosis | PRKCG,BIN1,INPP5D,PIK3CB,SYK,RAC2,FCGR3A,PLA2G4A,MARCKSL1,PLA2G4F |
| BDNF signaling pathway | CDK5,DOK5,YBX1,DPYSL2,SIRPA,EIF4E,EIF4EBP1,CDH2,JAK2,EEF2 |
| CDC42 signaling events | CDC42BPA,ACTR2,ARPC4,PAK4,TNK2,ARPC3,ARPC1B,IQGAP3,ARPC2,ARPC5 |
| EPHB-mediated forward signaling | ARPC4,ACTR3,EPHB4A,ARPC3,ARPC5,EFNB2,KALRN,EPHB3A,ARPC2,EPHB4B |
| Axon guidance | Plxna2,ARPC4,EFNB3B,PAK6,PPP3R1,COL9A1,SRGAP3,ST8SIA2,RND1,MYL12A |
| EPH-Ephrin signaling | CLTC,MYL12B,ACTR2,KALRNB,EFNB3,EFNB2A,EFNB3B,EPHA10,EPHB3A,EPHB4A |
Protein Function
CFL1 has several biochemical functions, for example, actin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFL1 itself. We selected most functions CFL1 had, and list some proteins which have the same functions with CFL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | ACTN3B,EPS8L2,GSNB,MYPN,WASF3B,ACTN3,STK38L,FHOD3,CALD1,Fert2 |
| protein binding | CTAG1B,MOBKL1A,TBRG4,BCL7A,NACC2,C4BPB,MCCC1,MTCH1,EFHC2,SMARCD1 |
Interacting Protein
CFL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CFL1.
ACTB;ACTG1;YWHAZ;ARRB2;ARRB1
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References
- Nakashima, J; Laosinchai, W; et al. New insight into the mechanism of cellulose and callose biosynthesis: proteases may regulate callose biosynthesis upon wounding. CELLULOSE 10:369-389(2003).
- Cui, XJ; Shin, HS; et al. A putative plant homolog of the yeast beta-1,3-glucan synthase subunit FKS1 from cotton (Gossypium hirsutum L.) fibers. PLANTA 213:223-230(2001).
