CELF1
- Product List
- Overview
- Review / Q&A
-
Official Full Name
CUGBP, Elav-like family member 1 -
Overview
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
CELF1;CUGBP, Elav-like family member 1;CUG triplet repeat, RNA binding protein 1 , CUG triplet repeat, RNA binding protein 1 , CUGBP1;CUGBP Elav-like family member 1;bruno like 2;BRUNOL2;CUG RNA binding protein;CUG BP;CUGBP;EDEN BP;embryo deadenylation element binding protein;hNab50;NAB50;NAPOR;nuclear polyadenylated RNA binding protein;50 kD;50 kDa Nuclear polyadenylated RNA binding protein;Deadenylation factor CUG BP;RNA binding protein BRUNOL 2;50 kDa nuclear polyadenylated RNA-binding protein;bruno like protein 2;Bruno-like protein 2;BRUNOL 2;CELF 1;CELF-1;CELF1 CUGBP, Elav like family member 1;CELF1_HUMAN;CUG BP and ETR 3 like factor 1;CUG BP1;CUG triplet repeat RNA binding protein 1;CUG triplet repeat RNA-binding protein 1;CUG-BP- and ETR-3-like factor 1;CUG-BP1;CUGBP 1;CUGBP and ETR3 like factor 1;CUGBP Elav like family member 1;CUGBP1;Cytidine Uridine Guanosine Binding Protein 1;Deadenylation factor CUG-BP;Deadenylation factor CUGBP;EDEN BP homolog;EDEN-BP homolog;embryo deadenylation element binding protein homolog;Embryo deadenylation element-binding protein homolog;hNab 50;NAB 50;Nuclear polyadenylated RNA binding protein 50 kD;RNA binding protein BRUNOL2;RNA-binding protein BRUNOL-2;bruno-like 2;CUG RNA-binding protein;CUG;CUG-BP;EDEN-BP
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- DDK
- Myc
- Flag
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CUGBP1-11699H | Recombinant Human CUGBP1, His-tagged | E.coli | Human | His | 107-479a.a. | |
| CELF1-1330R | Recombinant Rat CELF1 Protein | Mammalian Cells | Rat | His |
|
|
| CELF1-1896C | Recombinant Chicken CELF1 | Mammalian Cells | Chicken | His |
|
|
| CELF1-2127H | Recombinant Human CELF1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| CELF1-3272M | Recombinant Mouse CELF1 Protein | Mammalian Cells | Mouse | His |
|
|
| CELF1-9152Z | Recombinant Zebrafish CELF1 | Mammalian Cells | Zebrafish | His |
|
|
| CELF1-1244H | Recombinant Human CELF1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
|
|
| CELF1-1436HFL | Recombinant Full Length Human CELF1 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
|
| CELF1-1567M | Recombinant Mouse CELF1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
|
| Celf1-2100M | Recombinant Mouse Celf1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
|
|
| CELF1-2391HF | Recombinant Full Length Human CELF1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 483 amino acids |
|
| CELF1-574H | Recombinant Human CELF1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
|
|
| CELF1-6334H | Recombinant Human CELF1 protein, His-tagged | E.coli | Human | His | 1-486a.a. |
|
| CELF1-705H | Recombinant Human CELF1 protein(T173E,S178D,S285D,S288D,S295D,S296D,S298D) | E.coli | Human | Non | 1-482aa (T173E,S178D,S285D,S288D,S295D,S296D,S298D) |
|
| CELF1-706H | Recombinant Human CELF1 protein(T173E,S178D,S285D,S288D,S295D,S296D,S298D,L404A,P405A) | E.coli | Human | Non | 1-482aa (T173E,S178D,S285D,S288D,S295D,S296D,S298D,L404A,P405A) |
|
| CELF1-707H | Recombinant Human CELF1 protein(T173E,S178D,S285D,S288D,S295D,S296D,S298D) | E.coli | Human | Non | 1-475aa (T173E,S178D,S285D,S288D,S295D,S296D,S298D) |
|
| CELF1-988R | Recombinant Rat CELF1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
|
Involved Pathway
CELF1 involved in several pathways and played different roles in them. We selected most pathways CELF1 participated on our site, such as Adipogenesis,mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CELF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | GATA2A,CEBPB,CYP26A1,CISD1,NAMPT,GTF3AA,BMP3,AGPAT2,MEF2AA,PLIN2 |
| mRNA processing | DHX15,SRSF10,CELF2,SRPK2,PTBP1,DDX39,METTL3,HNRNPAB,CD2BP2,CELF4 |
Protein Function
CELF1 has several biochemical functions, for example, BRE binding,RNA binding,mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CELF1 itself. We selected most functions CELF1 had, and list some proteins which have the same functions with CELF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| translation repressor activity, nucleic acid binding | CPEB1B,CPEB2,PURA,CPEB1,CELF4,CPEB4,PAIP2B,PPP1R2P9,CPEB3,CPEB1A |
| protein binding | RNF165,ROBO2,PCSK9,GCG,CRY1A,SULT4A1,AIMP1,PPP1R9A,DYNC2LI1,CACNA2D1A |
| translation initiation factor binding | TBL2,EIF3B,DDX3X,EIF2B4,EIF2B3,TRIM32,ZNF259,POLR2D,EIF3M,POLR2GL |
| nucleotide binding | CKMA,RBFOX1,CPSF6,C10orf28,GNA12A,ABCC12,ATP1A1A.4,RNPS1,TUBA1L,CIRBP |
| RNA binding | TEP1,RPL29,PATL2,PSMA1,ZMAT4,CWC22,RBM4.1,RPL26,EIF3K,BXDC2 |
| BRE binding | CELF4 |
| poly(A) RNA binding | SECISBP2,BCLAF1,BOP1,PSIP1,MRPS14,CRNKL1,KPNA2,RBM34,DDX5,MANF |
| mRNA binding | RPS3,DXO,TDRD7,FXR1,HNRNPAB,CSTF2T,SOSTDC1B,CELF4,CPSF5,PARK7 |
Interacting Protein
CELF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CELF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CELF1.
HNRNPH1;USP10;MBNL1;TOM1L1;PPBP;HNRNPC;FUBP1;RALY;ssrna_cg;PTBP3
Resources
Related Services
Related Products
References
- Morgan, GT; et al. Localized co-transcriptional recruitment of the multifunctional RNA-binding protein CELF1 by lampbrush chromosome transcription units. CHROMOSOME RESEARCH 15:985-1000(2007).
