CEL
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Official Full Name
carboxyl ester lipase -
Overview
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008] -
Synonyms
CEL;carboxyl ester lipase;BAL;FAP;BSDL;BSSL;CELL;FAPP;LIPA;CEase;MODY8;bile salt-activated lipase;bucelipase;sterol esterase;cholesterol esterase;carboxyl ester hydrolase;fetoacinar pancreatic protein;lysophospholipase, pancreatic;bile salt-dependent lipase, oncofetal isoform;carboxyl ester lipase (bile salt-stimulated lipase)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Cel-01MFL |
Active Recombinant Full Length Mouse carboxyl ester lipase Protein, His Tagged
|
Baculovirus | Mouse | His | Full L. 1-599aa |
|
| CEL-1109H | Recombinant Human CEL Protein, GST-Tagged | Wheat Germ | Human | GST |
|
|
| CEL-2168C | Recombinant Chicken CEL | Mammalian Cells | Chicken | His |
|
|
| Cel-488M | Recombinant Mouse Cel protein, His-tagged | Insect Cells | Mouse | His | 1-534 a.a. |
|
| CEL-0845H | Recombinant Human CEL Protein (Asp117-Glu361), N-His tagged | E.coli | Human | His | Asp117-Glu361 |
|
| CEL-569H | Recombinant Human CEL Protein, His/GST-tagged | E.coli | Human | GST&His | Asp117~Glu361 |
|
Involved Pathway
CEL involved in several pathways and played different roles in them. We selected most pathways CEL participated on our site, such as Steroid biosynthesis,Glycerolipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CEL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GM5506,CCBL1,SMPD1,ASS1,POLR2L,CYP3A65,HYAL6,SLC27A5,ADH7,POLR2J2 |
| Pancreatic secretion | SLC9A1,ATP1A1,BST1,FXYD2,PRKCG,PLCB2,PNLIPRP2,CPB1,PNLIP,ATP1B2 |
| Fat digestion and absorption | PLA2G3,DGAT2,ABCA1,FABP2,LIPF,APOA1,PNLIPRP2,PLA2G2A,PLA2G2F,SLC27A4 |
| Glycerolipid metabolism | AGPAT6,AGPAT5,PPAP2D,ALDH9A1A.1,CELL,GLYCTK,AKR1B8,PPAP2CB,ALDH3A2A,ALDH7A1 |
| Steroid biosynthesis | DHCR24,EBP,CPN1,LSS,SC5DL,CEL.1,CYP2R1,SQLE,SOAT1,FAXDC2 |
Protein Function
CEL has several biochemical functions, for example, 1-oxa-2-oxocycloheptane lactonase activity,3,4-dihydrocoumarin hydrolase activity,Ala-tRNA(Pro) hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CEL itself. We selected most functions CEL had, and list some proteins which have the same functions with CEL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endosulfan lactone lactonase activity | CES1C,PNPLA7,CELL,LIPK,LIPN,Aadacl3,ABHD2B,LIPM,DAGLB,CEL.1 |
| lipase activity | CELL,AADAC,GOLT1BB,LIPN,LIPM,LIPA,LYPLA1,GOLT1B,CEL.1,ABHD2B |
| retinyl-palmitate esterase activity | CES1C,CEL.1,Aadacl3,ABHD2B,LIPM,NOTUM1A,PNPLA7,CELL,LIPK,ABHD2A |
| L-ascorbate 6-phosphate lactonase activity | ABHD2B,Aadacl3,PNPLA7,LIPK,CELL,LIPM,CEL.1,ABHD2A,CES1C,DAGLB |
| mannosyl-oligosaccharide 1,6-alpha-mannosidase activity | LIPM,ABHD2B,CELL,LIPN,NOTUM1A,Aadacl3,CES1C,PNPLA7,CEL.1,ABHD2A |
| glycosphingolipid binding | SELP,Il2,LAMB1,SELL,LAMA1,LAMC1,LYN |
| lysophospholipase activity | PNPLA6,PLA2G4A,ENPP2,LYPLAL1,ASPG,PNPLA8,PLA2G15,PNPLA7,LGALS13,MGLL |
| sulfolactone hydrolase activity | PNPLA7,LIPN,DAGLB,NOTUM1A,CEL.1,LIPK,CELL,CES1C,LIPM,Aadacl3 |
| Cys-tRNA(Pro) hydrolase activity | LIPM,LIPK,CELL,CEL.1,PNPLA7,Aadacl3,ABHD2A,LIPN,CES1C,DAGLB |
Interacting Protein
CEL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEL here. Most of them are supplied by our site. Hope this information will be useful for your research of CEL.
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References
- Baden, LR; Liu, JY; et al. Induction of HIV-1-Specific Mucosal Immune Responses Following Intramuscular Recombinant Adenovirus Serotype 26 HIV-1 Vaccination of Humans. JOURNAL OF INFECTIOUS DISEASES 211:518-528(2015).
- Gotlib, J; et al. CME Information: World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management. AMERICAN JOURNAL OF HEMATOLOGY 89:325-337(2014).
