CD8B
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Official Full Name
CD8b molecule -
Overview
CD8b antigen is also known as T8, Lyt2, Ly-2, and CD8beta. It is a member of the immunoglobulin superfamily expressed on most thymocytes, some mature T cell subsets, and macrophages. CD8b forms heterodimers with the CD8alpha chain (CD8a). CD8 is an antige -
Synonyms
CD8B;CD8b molecule;CD8 antigen, beta polypeptide 1 (p37) , CD8B1;T-cell surface glycoprotein CD8 beta chain;CD8 antigen, beta polypeptide 1 (p37);T lymphocyte surface glycoprotein beta chain;LY3;P37;LEU2;LYT3;CD8B1;MGC119115
Recombinant Proteins
- Human
- Rat
- Chicken
- Cynomolgus
- Rabbit
- Mus musculus
- Pongo Pygmaeus
- Felis catus
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- Human Cells
- In Vitro Cell Free System
- GST
- His
- Non
- Fc
- Avi
Involved Pathway
CD8B involved in several pathways and played different roles in them. We selected most pathways CD8B participated on our site, such as Cell adhesion molecules (CAMs),Antigen processing and presentation,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD8B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | CD74,HLA-DRA,KIR2DL1,TNF,HLA-DQA1,HLA-C,KIR2DL4,KIR2DS5,H2-AB1,HSP90AB1 |
| nodeficiency | BTK,CD19,CD79A,AIRE,IKBKG,LCK,CD8A,UNG,TAP2,DCLRE1C |
| T cell receptor signaling pathway | SOS1,MAPK11,CD28,NFATC1,VAV2,AKT2,NFKB1,IKBKB,PIK3CA,MAP3K7 |
| Hematopoietic cell lineage | Il6ra,ITGA6,CD37,CSF1,IL3,ITGA2B,IL1R1,CD2,EPOR,GYPA |
| Cell adhesion molecules (CAMs) | CLDN19,CLDN5,ITGA4,NRCAMA,MAG,MHC2DAB,ICOSLG,VCAN,CNTN1A,CD8A |
| Primary i | TNFRSF13B,IL7R,RFXANK, Cd79b,UNG,BLNK,CD8B1,RAG1,ICOS,TAP1 |
Protein Function
CD8B has several biochemical functions, for example, MHC class I protein binding,coreceptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD8B itself. We selected most functions CD8B had, and list some proteins which have the same functions with CD8B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class I protein binding | TUBB4B,DERL1,TUBB,HLA-E,LILRB1,ATP5A1,CD244,CD8A,LILRB2,PILRB2 |
| coreceptor activity | CD86,CCR5,RGMB,TGFBR3,PVRL2,HFE2,RAMP1,LY96,PVRL1,ACVR2A |
| protein binding | SMCO4,HACE1,CA4,PVRL4,SH3PXD2B,NPY2R,DBF4B,LRCH3,ZNF843,CCBL1 |
Interacting Protein
CD8B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD8B here. Most of them are supplied by our site. Hope this information will be useful for your research of CD8B.
Resources
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References
- Cooney, LA; Gupta, M; et al. Short-Lived Effector CD8 T Cells Induced by Genetically Attenuated Malaria Parasite Vaccination Express CD11c. INFECTION AND IMMUNITY 81:4171-4181(2013).
- Clement, M; Ladell, K; et al. Anti-CD8 Antibodies Can Trigger CD8(+) T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide-MHCI Tetramer Staining. JOURNAL OF IMMUNOLOGY 187:654-663(2011).
