CD81
-
Official Full Name
CD81 antigen -
Overview
CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1. CD81 is expressed on T and B cells, NK cells, dendritic cells, thymocytes, endothelial cells and fibroblasts. CD81 induces B cell adhesion via the VLA-4 -
Synonyms
CD81;CD81 antigen;26 kDa cell surface protein TAPA-1;target of the antiproliferative 1;Tapa1;Tapa-1;Tspan28
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Rhesus macaque
- Zebrafish
- Cynomolgus
- Chlorocebus Aethiops
- Bovine
- Saguinus oedipus (Cotton-top tamarin)
- Pan troglodytes
- E.coli
- CHO
- HEK293
- Insect Cell
- Wheat Germ
- Mammalian Cell
- Human Cell
- Mammalian cells
- Human cells
- Yeast
- HEK293T
- E.coli expression system
- His
- Fc
- Non
- His&Flag&Avi
- GST
- mFc
- His&T7
- Flag
- His&Fc&Avi
- His&Fc
- His&SUMO
- Myc&DDK
- N-His&C-Myc
Involved Pathway
CD81 involved in several pathways and played different roles in them. We selected most pathways CD81 participated on our site, such as B cell receptor signaling pathway,Malaria,Hepatitis C, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD81 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Malaria | MET,TGFB1,CCL2,GYPB,IL18,GYPC,TNF,IL1B,TGFB2,HBB |
| Hepatitis C | KRAS,IRF7,NR1H3,CLDN22,RAF1,MAPK9,IFNA8,IFN-a,IFNA7,GSK3B |
| B Cell Receptor Signaling Pathway | CDK2,NFATC3,MAPK1,CD22,MAP4K1,PIK3AP1,BCL10,TTC6,INPPL1,SYK |
Protein Function
CD81 has several biochemical functions, for example, MHC class II protein complex binding,protein binding,transferrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD81 itself. We selected most functions CD81 had, and list some proteins which have the same functions with CD81. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferrin receptor binding | TF,HFE,HFE2,RGMA,SNX2,SNX1,SNX4,Trf |
| MHC class II protein complex binding | HLA-DMB,ATP1B1,HLA-DRB1,HLA-DMA,PKM2,HLA-DOA,HSP90AB1,PKM,YWHAE,HLA-DRA |
| protein binding | CFL1,HPS6,MRM1,ZRANB1,TBC1D10C,IPO7,SAC3D1,SETD6,CLOCKB,NUCB2 |
Interacting Protein
CD81 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD81 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD81.
p27958-pro_0000037570;SRFBP1;HLA-B;q99ib8-pro_0000045596;TRAF6;JAK3;CSNK2B;ZBTB16
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References
- Xiao, F; Fofana, I; et al. Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C. GUT 64:483-+(2015).
- Meola, A; Tarr, AW; et al. Structural Flexibility of a Conserved Antigenic Region in Hepatitis C Virus Glycoprotein E2 Recognized by Broadly Neutralizing Antibodies. JOURNAL OF VIROLOGY 89:2170-2181(2015).
