CCNT2
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Official Full Name
cyclin T2 -
Overview
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants. -
Synonyms
CCNT2;cyclin T2;cyclin-T2;CCNT2_HUMAN;CycT2;FLJ90560;MGC134840;cyclin T2a;cyclin T2b;OTTHUMP00000162502;OTTHUMP00000162503;SDS-stable vimentin-bound DNA fragment HEF42VIM22;subunit of positive elongation transcription factor b
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CCNT2-0682H | Recombinant Human CCNT2 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CCNT2-27017TH | Recombinant Human CCNT2 | Wheat Germ | Human | Non | 107 amino acids |
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| CCNT2-7701HCL | Recombinant Human CCNT2 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
CCNT2 involved in several pathways and played different roles in them. We selected most pathways CCNT2 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | BCL2L1,TRP53,IGF1,TRAF1,PBX1,ETV6,SLC45A3,ASPSCR1,TMPRSS2,HMGA2 |
Protein Function
CCNT2 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNT2 itself. We selected most functions CCNT2 had, and list some proteins which have the same functions with CCNT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | CCNL2,CCNE1,CCNK,CCNC,CDK4,CCNT1,CKS1B,CCNL1A,PSTPIP2,CCND1 |
Interacting Protein
CCNT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNT2.
CDK9;q81qg7_bacan;Aff1;ELL2;MED26;MLLT3;Mllt1;AFF4
Resources
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References
- Krueger, BJ; Varzavand, K; et al. The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK. PLOS ONE 5:-(2010).
- Wang, M; Sun, L; et al. Cyclin D1 as a universally expressed mantle cell lymphoma-associated tumor antigen for immunotherapy. LEUKEMIA 23:1320-1328(2009).
