CCNE1

  • Official Full Name

    cyclin E1

  • Overview

    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]

  • Synonyms

    CCNE1;cyclin E1;CCNE;G1/S-specific cyclin-E1;cyclin Es;cyclin Et;cyclin E variant ex5del;cyclin E variant ex7del

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Zebrafish
  • E.coli
  • Insect Cells
  • Wheat Germ
  • Sf9 Cells
  • Mammalian Cells
  • In Vitro Cell Free System
  • GST
  • His
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
CCNE1-11754H Recombinant Human CCNE1, GST-tagged E.coli Human GST C-term-300a.a.
CCNE1-3075H Recombinant Human CCNE1 protein, His-tagged Insect Cells Human His Met1-Ala410
CCNE1-2926H Recombinant Human CCNE1 protein, His-tagged E.coli Human His 364-410 aa
CCNE1-259H Active Recombinant Human CCNE1 Protein, His & GST-tagged Insect Cells Human GST&His Full L. 1-410 a.a.
CCNE1-0665H Recombinant Human CCNE1 Protein, GST-Tagged Wheat Germ Human GST
CCNE1-27521TH Recombinant Human CCNE1 Sf9 Cells Human Non 410 amino acids
CCNE1-3011C Recombinant Chicken CCNE1 Mammalian Cells Chicken His
CCNE1-31090TH Recombinant Human Human CCNE1 Human Non Full L.
CCNE1-416M Recombinant Mouse CCNE1, His-GST tagged Insect Cells Mouse Non 1-408 a.a.
CCNE1-522H Recombinant Human CCNE1, Gly & Pro tagged Insect Cells Human His 1-410 a.a.
CCNE1-8630Z Recombinant Zebrafish CCNE1 Mammalian Cells Zebrafish His
CCNE1-001MCL Recombinant Mouse CCNE1 cell lysate Insect Cells Mouse Non
CCNE1-666HCL Recombinant Human CCNE1 cell lysate Insect Cells Human Non
CCNE1-001H Recombinant Human cyclin E1 protein, His tagged E.coli Human His 16-143 aa
CCNE1-2971HF Recombinant Full Length Human CCNE1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 410 amino acids
CCNE1-3244M Recombinant Mouse CCNE1 protein(Met1-Glu408), His&GST-tagged Insect Cells Mouse GST&His Met1-Glu408

    Involved Pathway

    CCNE1 involved in several pathways and played different roles in them. We selected most pathways CCNE1 participated on our site, such as Cell cycle,Oocyte meiosis,p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hepatitis B TGFBR1,IFNA2,IFNA16,MMP9,BIRC5,STAT5A,HSPG2,PIK3CA,IFNA21,CREB3L1
    Small cell lung cancer TRAF6,IKBKB,RXRA,RELA,PIK3R5,PIAS2,TRAF1,ITGA2,AKT2,TRAF3
    Prostate Cancer KRAS,IGF1,CREB3L1,IGF1R,NFKB1,HSP90B1,TP53,SOS1,RAF1,CREB3L2
    Oocyte meiosis ANAPC13,CAMK2D1,RPS6KA3,CAMK2D,YWHABB,SMC1A,CPEB1A,IGF1RB,CDC27,SPDYB
    p signaling pathway CD82A,TNFRSF10B,PMAIP1,CCNG2,CASP9,BAXA,RPRMA,SFN,PTENA,IGF1
    Viral carcinogenesis CDK1,HIST1H4F,RAC1,GTF2A2,YWHAB,KAT2A,TRP53,NFKB1,BAX,EGR3
    Pathways in cancer SFPI1,FOXO1,FZD1,RUNX1,NRAS,EPAS1,FGF22,TGFA,FLT3,FLT3LG
    Cell cycle TGFB3,RAD1,DCTN2,FOXM1,CDC20,CDKN1C,PRKDC,RBBP7,LMNB1,NSL1
    PIK-Akt signaling pathway G6PC2,ITGB8,GNG7,TCL1B1,MAP2K2,IFNA14,FGF1,INS1,NGF,PDGFB

    Protein Function

    CCNE1 has several biochemical functions, for example, androgen receptor binding,cyclin-dependent protein serine/threonine kinase regulator activity,kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNE1 itself. We selected most functions CCNE1 had, and list some proteins which have the same functions with CCNE1. You can find most of the proteins on our site.

    Function Related Protein
    transcription coactivator activity TAF5L,YAP1,ESR2,TAF10,MED13,GTF2A2,TFAP2A,ECD,PMF1,SUB1A
    androgen receptor binding PIAS1,NSD1,WIPI1,BRCA1,RB1,NCOA4,KDM4C,GRIP1,PRPF6,CDK7
    protein binding DTX3,RAB5C,MXD1,UBXN2B,TBX18,TIMP3,IL13,DGCR6L,CCDC28A,RABGAP1L
    kinase activity STK38A,MAPK14B,PKMA,HYKK.2,ADKA,ACVR1BA,PLK1,CAMKK1A,PIK3R3B,NEK1
    protein complex binding MLC1,KRAS,NFKBIA,CFLAR,ING2,TULP2,PCSK2,NCOA1,ANKRD32,KAT2B
    cyclin-dependent protein serine/threonine kinase regulator activity CCNC,CCNT1,CCNT2B,CCNY,PSTPIP2,CKS2,CCNL1A,CCNT2A,CDK4,CCNK
    protein kinase binding PTPRC,CDKN2B,PARN,WAS,FBXO7,DOK7,SPDYB,IL12RB2,PPP1CB,MAP3K2

    Interacting Protein

    CCNE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNE1.

    CDK2;CDKN1A

    CCNE1 Related Signal Pathway

    Resources

    Research Area

    G1 (Restriction) Checkpoints
    Cyclins
    Oncoprotein-Cell Cycle

    References

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