CCNA2
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Official Full Name
cyclin A2 -
Overview
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a;dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination;of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all;tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M;transitions. -
Synonyms
CCNA2;cyclin A2;CCN1, CCNA;cyclin-A2;cyclin-A;CCN1;CCNA
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- E.coli
- Human
- Wheat Germ
- Mammalian Cell
- Insect Cell
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- His
- Non
- GST
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CCNA2 involved in several pathways and played different roles in them. We selected most pathways CCNA2 participated on our site, such as Cell cycle,AMPK signaling pathway,Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | PIK3CA,SREBF1,STK11,PRKAG2,SIRT1,GYS2,IRS4,G6PC3,EEF2K,IGF1R |
| Epstein-Barr virus infection | SFPI1,PSMD13,HLA-DQA1,PSMC4,GTF2B,ITGAL,TRAF6,PSMD4,YWHAZ,PIK3R5 |
| Hepatitis B | PIK3CA,PTK2B,RAF1,MAPK3,EGR3,TRP53,MAP2K4,TICAM2,TGFB1,CCNE1 |
| Progesterone-mediated oocyte maturation | ANAPC4,AKT2L,MAD2L2,KRAS,CDC26,ANAPC13,IGF1RA,ADCY1B,MAD1L1,CDC16 |
| Cell cycle | FZR1A,RANGAP1B,CDKN1BB,KIF18A,MIS18BP1,STAG1,CSNK1D,BUB1,PDS5B,RNF168 |
| Viral carcinogenesis | CASP8,PSMC1,SRF,PIK3R5,HIST1H4F,GTF2A1,HIST1H4J,STAT5B,PIK3CA,CCND3 |
Protein Function
CCNA2 has several biochemical functions, for example, protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNA2 itself. We selected most functions CCNA2 had, and list some proteins which have the same functions with CCNA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | PRKAB1,SHC1,Cd24a,FOXO3,RHEB,KIF14,FBXO5,SPRED1,TCF7L2,PTEN |
| protein binding | GAP43,RBM4,HLTF,RSAD2,LAGE3,TWSG1,RSPO1,DAAM1,MPLKIP,DHX58 |
Interacting Protein
CCNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNA2.
CDK2
Resources
Research Area
Negative Regulators of EMTExtracellular Matrix Molecules
Melanoma Biomarkers
G1 (Restriction) Checkpoints
Cyclins
Related Services
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References
