CCNA1
-
Official Full Name
cyclin A1 -
Overview
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CCNA1;cyclin A1;cyclin-A1;OTTHUMP00000018259;Cyclin A
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Insect Cells
- Wheat Germ
- Mammalian Cell
- Sf9 Insect Cell
- Insect Cell
- Mouse
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- His&GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CCNA1 involved in several pathways and played different roles in them. We selected most pathways CCNA1 participated on our site, such as Cell cycle,AMPK signaling pathway,Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acute myeloid leukemia | MYC,PIK3R3,PIK3CB,RUNX1T1,ARAF,RELA,PML,RAF1,PIM2,SOS1 |
| Pathways in cancer | ARNT,WNT10B,PLCB4,PTGS2,BCL2L1,LAMA2,PTK2,BIRC3,IGF1,TGFB1 |
| Transcriptional misregulation in cancer | PML,PAX3,SMAD1,IL6,NGFR,MLF1,LRP2BP,HIST1H3G,ARNT2,CD40 |
| Hepatitis B | DDX58,APAF1,CASP12,TGFB1,MAPK1,MYD88,BIRC5,PIK3R1,TGFB2,CCND1 |
| Viral carcinogenesis | PIK3R3,IRF3,HLA-F,GTF2H2C,BAK1,HNRNPK,TRAF1,HIST1H4J,SCIN,VAC14 |
| AMPK signaling pathway | TSC2,PFKFB4,SLC2A4,PPP2R3C,IGF1,PFKP,PFKM,TBC1D1,PRKAA2,PPARG |
| Progesterone-mediated oocyte maturation | CCNB1,ANAPC2,INS1,BRAF,CCNA2,PIK3CA,PPP1R2P9,BUB1,ANAPC11,MOS |
| Cell cycle | ANKLE2,CEP76,SMC1B,ARPP19B,ESCO2,CTDNEP1,E2F3,BARD1,TUBGCP3,CDK2 |
| Epstein-Barr virus infection | POLR2E,HSPA1A,HSPB1,POLR2L,ENTPD8,POLR3F,YWHAB,TRAF1,POLR2A,RELB |
Protein Function
CCNA1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNA1 itself. We selected most functions CCNA1 had, and list some proteins which have the same functions with CCNA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MTA3,HPCAL1,PCSK9,NIF3L1,ITCH,RASSF1,SYNJ2,UBR1,TRAM2,RPL30 |
Interacting Protein
CCNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNA1.
CDKN1A;PTK2;MCM4;MCM6;EIF3F;PFAS;TGFB1I1;GOT2;e1a_ade05;OAT;MTHFD1;PAICS;MCC;CDK2;MCM3;APEX1;VHL
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