CAPN3
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Official Full Name
calpain 3, (p94) -
Overview
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008] -
Synonyms
CAPN3;calpain 3, (p94);p94;CANP3;LGMD2;nCL-1;CANPL3;LGMD2A;calpain-3;calpain L3;new calpain 1;calpain, large polypeptide L3;calcium-activated neutral proteinase 3;calpain p94, large [catalytic] subunit;muscle-specific calcium-activated neutral protease 3 large subunit
Recombinant Proteins
- Human
- Rat
- Chicken
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
CAPN3 involved in several pathways and played different roles in them. We selected most pathways CAPN3 participated on our site, such as Integrin-mediated cell adhesion,TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF-alpha/NF-kB Signaling Pathway | COPS3,KPNA6,CRADD,KTN1,CSNK2A1P,PFDN2,RNF25,SMARCB1,KIAA1967,PEG3 |
| Integrin-mediated cell adhesion | MAPK6,CAPN10,CAPN9,CAPN11,MYLK2,TNS1,CAPNS1,SEPP1A,CAPN5,MAPK4 |
Protein Function
CAPN3 has several biochemical functions, for example, calcium ion binding,calcium-dependent cysteine-type endopeptidase activity,catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPN3 itself. We selected most functions CAPN3 had, and list some proteins which have the same functions with CAPN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | CD24,FLNA,SHISA5,PLCD4,VIPR1B,OLFCG3,PLCZ1,MAVS,CC2D1A,OPN4XA |
| titin binding | MYBPC3,MYBPC1,CALM3,TRIM63,ACTN2,ANKRD23,ANKRD1B,CALM1,ANKRD2,CALM2 |
| sodium ion binding | PDXK,SCN9A,ATP1A1,SLC34A2,SLC24A2,SLC24A1,SLC24A5,SLC24A4A,SLC24A4 |
| protein binding | CIB2,SFN,BMX,P2RX4,USH1G,AIDA,CYBB,CSRP2BP,Ctsl,PACSIN1 |
| calcium ion binding | FKBP10,CD69,CDH6,DLL4,REPS1,PCDHA9,ATP2A1,FSTL1,RCV1,SRI |
| cysteine-type peptidase activity | CAPN12,USP43,CAPN2,CASP7,GM12824,USP27X,USP43A,PGPEP1,CASPA,USP12A |
| protein complex scaffold | AKAP13,SMARCD1,ISCU,WWC1,AKAP9,CHCHD3,MAP2K2,CAV1,TELO2,MAGI3 |
| calcium-dependent cysteine-type endopeptidase activity | CAPN3B,CAPN5,SOLH,CAPNS1B,CAPN10,PDCD6,CAPN9,CAPN1A,CAPNS1A,CAPN2 |
| structural constituent of muscle | MYL2,MYBPC1,MYL6B,ACTN3,CSRP3,COX4I2,TCAP,PDLIM3,JPH1,OBSCN |
Interacting Protein
CAPN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPN3.
WDYHV1;OSGIN1;TTN;CRYAB;MMP2;C1QTNF9;PSMC3;MYBPC1;MYBPH;PREPL;AMOT;FNDC3B
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