CACNG3
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Official Full Name
calcium channel, voltage-dependent, gamma subunit 3 -
Overview
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. -
Synonyms
CACNG3;calcium channel, voltage-dependent, gamma subunit 3;voltage-dependent calcium channel gamma-3 subunit;CACNG 3;Cacng2;Calcium channel voltage dependent gamma subunit 3;Neuronal voltage gated calcium channel gamma 3 subunit;Voltage dependent calcium channel gamma 3 subunit;Voltage gated calcium channel gamma subunit;TARP gamma-3;voltage-gated calcium channel gamma subunit;transmembrane AMPAR regulatory protein gamma-3;neuronal voltage-gated calcium channel gamma-3 subunit
Recombinant Proteins
- Human
- Rat
- Mouse
- Cynomolgus
- Rhesus macaque
- Chicken
- Pongo Abelii
- Bovine
- Mus musculus
- Macaca fascicularis
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
CACNG3 involved in several pathways and played different roles in them. We selected most pathways CACNG3 participated on our site, such as Adrenergic signaling in cardiomyocytes,Arrhythmogenic right ventricular cardiomyopathy,Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | KIF4,AP2M1,TCF3A,MED29,NR2F2,ACTR2B,HFE2,DOCK1,STX1B,TCF3B |
| Dilated cardiomyopathy | ITGB5,ITGA7,GNAS,CACNG4,SLC8A1,ITGAV,ITGB7,TGFB3,TPM4,PRKACB |
| Hypertrophic cardiomyopathy (HCM) | CACNA2D4,ITGB8,ITGA6,ITGA10,TGFB2,ACTC1,RYR2,CACNA2D1,PRKAG1,MYH7 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | TCF7,CACNB2,CACNG7,EMD,CTNNA1,ATP2A2,CACNA2D4,ACTB,ITGB7,ITGB6 |
| Adrenergic signaling in cardiomyocytes | PPP1CBL,PPP2R2D,PPP2R2B,CACNG8,ATP1B2A,PIK3CA,ATP2B3B,BCL2,PPP1CAB,PPP2R5D |
| Cardiac muscle contraction | MYH7,CACNA1C,CACNA2D4,TPM4,VMHC,UQCR10,CACNG6A,ACTC1A,UQCRC2B,CACNG8 |
| Arrhythmogenic right ventricular cardiomyopathy | CACNG2,DSC2,CDH2,DES,CTNNA1,JUP,DMD,DSG2,DAG1,CTNNA2 |
| Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | CACNG2,GRIP1,HAND2,NSFB,MYO6,PICK1,NSFA,AKAP5 |
Protein Function
CACNG3 has several biochemical functions, for example, channel regulator activity,voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG3 itself. We selected most functions CACNG3 had, and list some proteins which have the same functions with CACNG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated calcium channel activity | CACNB2,CACNA1D,CACNB2A,TPC3,CACNG8A,CACNB4B,CACNG2B,CACNA1SA,OPRM1,TMC1 |
| channel regulator activity | CNIH3,SNF8,CACNG2,CACNG2A,CACNG2B,CACNG7,CACNG4,SLC9A3R2,CACNG8,CACNG7A |
Interacting Protein
CACNG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNG3.
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References
- Endoh, T; et al. Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius. BRAIN RESEARCH 1024:212-224(2004).
- Yamada, E; Endoh, T; et al. Angiotensin II-induced inhibition of calcium currents via G(q/11)-protein involving protein kinase C in hamster submandibular ganglion neurons. NEUROSCIENCE RESEARCH 43:179-189(2002).
