C1qtnf9

What is C1QTNF9 Protein?

C1QTNF9 protein is part of a unique family that includes roles in immune response and metabolism regulation. It's quite similar to adiponectin, which helps manage sugar and fat levels in the body. Scientists are exploring what C1QTNF9 actually does, but there’s a good chance it’s linked to inflammation and energy balance. Given its similarity to certain proteins, it might also relate to issues like obesity and diabetes. Cracking the case with C1QTNF9 could lead to new treatments for metabolic disorders.

What is the Function of C1QTNF9 Protein?

C1QTNF9 protein is part of a family that plays important roles in how our bodies manage things like inflammation and metabolism. Although it’s still being studied, this protein is thought to be involved in balancing energy and potentially linking to conditions like obesity or diabetes. It’s structurally similar to adiponectin, which is known for regulating glucose and fat, suggesting C1QTNF9 might have similar jobs. As scientists continue to explore its function, there's hope that understanding C1QTNF9 could lead to breakthroughs in treating metabolic conditions.

C1QTNF9 Related Signaling Pathway

C1QTNF9 is a bit of a mystery, but it's thought to be linked to some key signaling pathways in the body. These pathways are like communication highways, sending signals that help regulate various functions, such as inflammation and metabolism. C1QTNF9 might interact with pathways related to energy balance, possibly affecting how the body processes glucose and fat. Its relationship with these pathways suggests it could play a part in conditions like diabetes or obesity. Researchers are interested in its potential to impact these diseases, hoping to unlock new treatments by understanding how C1QTNF9 fits into the big picture of cellular signaling.

C1QTNF9 Related Diseases

C1QTNF9 protein might not be a household name, but it's potentially tied to some significant health conditions. Researchers are looking into how this protein could be linked to diseases like obesity and diabetes. Given its similarities with proteins involved in regulating metabolism, C1QTNF9 might play a role in how our bodies store fat and use sugar. If it's affecting these processes, it could contribute to metabolic issues. Understanding C1QTNF9's function might offer new insights into treating or even preventing these diseases, making it an exciting focus for current scientific studies.

Bioapplications of C1QTNF9

C1QTNF9 might seem like just another protein, but it could have some cool bioapplications. Scientists are digging into its potential roles in health and medicine, especially given its links to metabolism and inflammation. If C1QTNF9 is involved in how our bodies handle glucose and fat, it might be a key player in tackling metabolic disorders like obesity or diabetes. Imagine new therapies or treatments that could emerge from these findings! Plus, since inflammation is another area of interest, it might even play a part in developing drugs for inflammatory conditions. All this makes C1QTNF9 a hot topic in research as experts figure out how to harness its potential for real-world healthcare solutions.

Case Study 1: Wong GW. et al. FASEB J. 2009

Adiponectin is a hormone from fat tissue that helps regulate sugar and fat in the body. There's a similar protein named CTRP9, closely related to adiponectin, mostly found in fat tissue and more in females than males. In younger ob/ob mice, its levels go up significantly. CTRP9 has some modifications and usually forms trimers, circulating in the blood, with changes based on sex and metabolism. It can mix with adiponectin to form complexes in mice. Their bond is through the globular C1q domain, without needing other parts. CTRP9 activates certain pathways in muscle cells and, when overexpressed in obese mice, it reduces blood sugar levels.

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  Fig1. Proteins were subjected to Western blot analysis using an anti-FLAG antibody.
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  Fig2. Gel filtration chromatographic analyses of FLAG-tagged adiponectin, adiponectin Cys mutant (C39A), CTRP9, or CTRP9 Cys mutant (C23A).

Case Study 2: Lee J. et al. Mol Cell Endocrinol. 2021

Autophagy is crucial in atherosclerosis. CTRP9, related to adiponectin, has anti-aging effects. This study explored if CTRP9 counteracts endothelial aging caused by palmitic acid (PA) by enhancing autophagy. Testing showed that CTRP9 reduces aging markers and boosts autophagy by adjusting LC3 and p62 protein levels. While PA disrupts autophagy, CTRP9 restores it by enhancing autophagic flow through AMPK activation, helping prevent cell aging from PA.

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  Fig3. Protein level of ppRB was measured after treatment with 3 μg/mL CTRP9 in the presence or absence of 500 μM PA.
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  Fig4. After HUVECS were treated at 37 °C with 3 μg/mL CTRP9 for different periods of time, the mRNA expression levels of ATG7 and ATG12 were determined.

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  Fig1. Signaling pathway related to neuroprotection and possible anti-aging effect of CTRP9. (Aysa Rezabakhsh, 2020)
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  Fig2. Signaling pathways regulated by CTRP9. (Hua Guan, 2022)

C1qtnf9 has several biochemical functions, for example, hormone activity,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C1qtnf9 itself. We selected most functions C1qtnf9 had, and list some proteins which have the same functions with C1qtnf9. You can find most of the proteins on our site.

Function	Related Protein
hormone activity	INS2,FNDC5B,RLN2,SST6,GCGA,AVP,INHBC,GAST,IGF1,UCN2
identical protein binding	DAPK1,HSP90AA1,CEACAM16,ALK,DYNLT1C,HSPB8,CLDN1,CNTN2,SORD,THBS1
protein binding	SYT11,MPP6,NUS1,MT2A,MLH1,MLANA,KIAA0649,PYY,DOCK2,CARD9

C1qtnf9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1qtnf9 here. Most of them are supplied by our site. Hope this information will be useful for your research of C1qtnf9.

C1QTNF9B;ADIPOQ;CAPN3;AMPD1;NDUFS1;RDX;UTRN;GYG1;MYOM1;NAP1L1;ACTC1;EIF4G2;MYBPC1;DST;DENND4A;TTN;LARP4B