C1QC
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Official Full Name
complement component 1, q subcomponent, C chain -
Overview
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. -
Synonyms
C1QC;complement component 1, q subcomponent, C chain;C1QG, complement component 1, q subcomponent, gamma polypeptide;complement C1q subcomponent subunit C;complement component 1, q subcomponent, gamma polypeptide;C1QG;C1Q-C;FLJ27103
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Rhesus macaque
- Human
- Mammalian Cell
- HEK293
- E.coli
- Mamanlian cells
- E. coli
- HEK293T
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
- His&GST
Involved Pathway
C1QC involved in several pathways and played different roles in them. We selected most pathways C1QC participated on our site, such as Complement and coagulation cascades,Prion diseases,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | HLA-DOA,HIST1H4F,HIST1H4M,H2AFB3,HIST1H2BJ,C1QB,FCGR3B,TNF,GRIN2A,HIST1H2AK |
| Chagas disease (American trypanosomiasis) | FOS,IKBKG,GNAQ,IFNB1,TGFBR1,IKBKB,PIK3CG,NOS2,SMAD2,PPP2R2B |
| Staphylococcus aureus infection | DSG1A,C1R,FPR3,HLA-DOA,HLA-DRB1,FCGR3A,FPR2,ICAM1,FCGR3B,FCGR1A |
| Prion diseases | PRKACA,HSPA5,C1QB,PRNP,C5,Hc,PRKACG,IL1B,LOC100033925,ELK1 |
| Pertussis | GNAI1,IL23,GNAI3,TLR4,C1S,RELA,C1QA,ITGAM,MAPK3,TICAM2 |
| Complement and coagulation cascades | BDKRB2,SERPINF2,C1QA,SERPIND1,C1RA,C1R,C3AR1,CFH,C3,VWF |
Protein Function
C1QC has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by C1QC itself. We selected most functions C1QC had, and list some proteins which have the same functions with C1QC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
C1QC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QC here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QC.
C1QA;TFAP2A;APOA1
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