BMP1
-
Official Full Name
bone morphogenetic protein 1 -
Overview
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008] -
Synonyms
BMP1;bone morphogenetic protein 1;PCP;TLD;OI13;PCP2;PCOLC;mammalian tolloid protein;procollagen C-proteinase 3;procollagen C-endopeptidase
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- GST&His
- Non
- Avi&Fc&His
Involved Pathway
BMP1 involved in several pathways and played different roles in them. We selected most pathways BMP1 participated on our site, such as Adipogenesis,Anchoring fibril formation,Assembly of collagen fibrils and other multimeric structures, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | NR2F1,E2F4,KLF5,MIXL1,EPAS1B,EGR2B,E2F1,PLIN2,MBNL1,NCOA2 |
| Degradation of the extracellular matrix | MMP8,ADAM8A,MMP15,TLDC2,ADAM8,MMP19,COL9A3,CMA1,COL17A1,ACAN |
| Cardiac Progenitor Differentiation | ZFP42,NIPAL1,T,NKX2,SIRPA,ROR2,IRX4,LIN28B,TBX20,TBX5 |
| Assembly of collagen fibrils and other multimeric structures | LOXL2,COL4A3,COL6A2,COL10A1A,MMP13,COL8A1,COL4A5,COL8A2,TLL1,COL5A3B |
| Collagen biosynthesis and modifying enzymes | COL5A3A,BMP1A,COL25A1,COL23A1,COL4A6,TLDC2,COL16A1,LEPREL2,COL4A3,COL28A1A |
| Crosslinking of collagen fibrils | LOXL2,LOXL1,BMP1B,LOXL3,LOX,TLL2,LOXL4,ABHD1,TLL1,PCOLCE |
| Anchoring fibril formation | BMP1B,TLL2,BMP1A,TLL1 |
| Collagen formation | CTSL1,DST,COL5A1,CD151,COL5A3B,EMID2,PCOLCE,TLL2,COL8A1A,SERPINH1B |
Protein Function
BMP1 has several biochemical functions, for example, calcium ion binding,cytokine activity,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP1 itself. We selected most functions BMP1 had, and list some proteins which have the same functions with BMP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metallopeptidase activity | MMP2,DPEP3,PSMD14,MEP1A.2,GM12824,TAF2,ADAM23,ADAMTS1,ADAM28,NPEPPS |
| peptidase activity | CAPN2A,KLK1B16,PRSS52,PSMB8F,ST14A,MCPT8,PSMB9A,Acr,PCSK5B,IHHA |
| calcium ion binding | CABP2,MYL2B,MELK,SCUBE1,PLCD1B,ANXA10,PCDH2AB8,CAPSL,ACTN2B,CRB1 |
| zinc ion binding | ESR1,KMT2A,AGBL1,KAT7,SRSF7,CA6,MMP24,MMP13A,GATA1,TRIML1 |
| growth factor activity | NGF,PPBP,PROK1,NENF,BMP16,GSDF,GRN,FGF8B,IL11,NRG2 |
| protein binding | REPS1,DTNBP1,CARD9,DDC,CREB3L3,CTR9,NT5C3B,MEOX1,PREP,STARD3 |
| cytokine activity | GDF9,IL6,IFNK,AREG,IL16,OSM,LIF,CMTM6,BMP10,Gm13290 |
| metalloendopeptidase activity | ADAMTSL5,ADAM2,ADAM22,XRCC6BP1,Adam6,FAP,SPG7,ADAMTS20,ADAMTS4,MEP1A.2 |
Interacting Protein
BMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP1.
MSTN;CHRD;TP53;ADRA1A;YLPM1;GEM;Uso1
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References
- Purushotham, S; Deivanayagam, C; et al. Cloning, expression and purification of the SRCR domains of glycoprotein 340. PROTEIN EXPRESSION AND PURIFICATION 90:67-73(2013).
- Grgurevic, L; Macek, B; et al. Bone morphogenetic protein (BMP)1-3 enhances bone repair. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 408:26-+(2011).
