BIRC6
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Official Full Name
baculoviral IAP repeat containing 6 -
Overview
Apollon (Q9NR09) is a ~500 kDa membrane associated inhibitor of apoptosis (IAP) protein. It encodes baculoviral-IAP-repeat (BIR) and ubiquitin-conjugating enzyme (UBC) domains at the N and C-termini, respectively. Unlike other IAPs Apollon encodes a chimeric E2/E3 ubiquitin ligase and is essential for inhibition of apoptosis in certain cell lines. Apollon inhibits apoptosis by promoting ubiquitination and degradation of active Smac and caspase-9, but Apollon also binds to and inactivates precursors of caspase-9 and Smac. Inactivation of Apollon also leads to upregulation and nuclear localization of p53,Which results in activation of caspase-2, Bax, and Bak, ultimately leading to mitochondrial apoptosis. -
Synonyms
BIRC6;baculoviral IAP repeat containing 6;baculoviral IAP repeat-containing protein 6;apollon;BRUCE;baculoviral IAP repeat-containing 6;ubiquitin-conjugating BIR domain enzyme apollon;ubiquitin-conjugating BIR-domain enzyme apollon;BIR repeat-containing ubiquitin-conjugating enzyme;FLJ13726;FLJ13786;KIAA1289
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BIRC6-1170H | Recombinant Human BIRC6 protein, His-tagged | E.coli | Human | His | Arg4576~Leu4857 |
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| BIRC6-230H | Recombinant Human BIRC6 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
BIRC6 involved in several pathways and played different roles in them. We selected most pathways BIRC6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
BIRC6 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC6 itself. We selected most functions BIRC6 had, and list some proteins which have the same functions with BIRC6. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
BIRC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC6.
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