BHLHE40
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Official Full Name
basic helix-loop-helix family, member e40 -
Overview
This gene encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. The encoded protein is believed to be involved in the control of cell differentiation. -
Synonyms
BHLHE40;basic helix-loop-helix family, member e40;basic helix loop helix domain containing, class B, 2 , BHLHB2, STRA13;class E basic helix-loop-helix protein 40;differentiated embryo chondrocyte expressed gene 1;DEC1;differentially expressed in chondrocytes 1;BHLHB2;Class B Basic Helix Loop Helix Protein 2;Class E basic helix loop helix protein 40;Differentially expressed in chondrocytes protein 1;Enhancer of split and hairy related protein 2;SHARP 2;Stimulated by retinoic acid gene 13 protein;STRA13;OTTHUMP00000147574;class B basic helix-loop-helix protein 2;enhancer-of-split and hairy-related protein 2;differentially expre;HLHB2;Stra14;SHARP-2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- N-StrepII and C-His
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BHLHE40 involved in several pathways and played different roles in them. We selected most pathways BHLHE40 participated on our site, such as Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with BHLHE40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian rhythm | RORB,CLOCK,CRY1,PRKAG3,RBX1,CSNK1E,SKP1,RORA,PRKAB2,FBXW11 |
Protein Function
BHLHE40 has several biochemical functions, for example, E-box binding,MRF binding,RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BHLHE40 itself. We selected most functions BHLHE40 had, and list some proteins which have the same functions with BHLHE40. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional repressor activity, RNA polymerase II transcription factor binding | AHRR,AHRRB,EOMES,PITX2,MINA,T,RIMKLB,TBX6,MLIP,AHRRA |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | TCF3,RELA,PRDM1,IFI203,SKIL,PROX1B,ATF3,NACC2,IFI16,PROX1A |
| transcription corepressor activity | CSDA,DNMT3B,WNT4,JUB,MXD1,MXD4,HOMEZB,LHX1,RBFOX2,TMEM38A |
| RNA polymerase II activating transcription factor binding | CTNNB1,LDB1,NEUROD1,LMO2,POU1F1,HNF4A,NFE2L2,EGR2,BEX1,CREBBP |
| bHLH transcription factor binding | TCF3,EP300,TWIST1,MAP3K10,USF2,USF1,TCF4,LMO2,SOX9,SP1 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | ELF2B,SPI1B,ATF4B2,FOXN1,SOX14,ETV4,SOX21,ZSCAN18,ATF5A,EF1 |
| protein domain specific binding | FOXA2,NR0B2,CRB3,WNT5A,NFE2L2,MITD1,CNOT1,VRK2,DRD3,HIST1H4A |
| protein homodimerization activity | ABAT,SLC11A1,GSS,Bcl2a1b,PDGFC,TOP2A,CDSN,ACOT7,GPD1L,TRIM37 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | SPI1,NFATC1,GATA4,CIR1,TLE4,HNF1B,CEBPA,MYF6,ATF1,MEF2C |
Interacting Protein
BHLHE40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BHLHE40 here. Most of them are supplied by our site. Hope this information will be useful for your research of BHLHE40.
UBE2I;KRTAP23-1;STK19;AAMP;SOX15;DAB1;CCNK
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