BAP1
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Official Full Name
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) -
Overview
BRCA1 Associated Protein 1 (BAP1) is an 81 kDa protein encoded by the BAP1 gene. It is proposed to be a tumour suppressor gene by enhancing the BRCA1 mediated inhibition of breast cancer cell growth. -
Synonyms
BAP1;BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase);ubiquitin carboxyl-terminal hydrolase BAP1;hucep 6;KIAA0272;UCHL2;cerebral protein 6;cerebral protein-13;TPDS;hucep-6;HUCEP-13;FLJ35406;FLJ37180;DKFZp686N04275
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- Rat
- Terciopelo
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
BAP1 involved in several pathways and played different roles in them. We selected most pathways BAP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
BAP1 has several biochemical functions, for example, chromatin binding,peptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAP1 itself. We selected most functions BAP1 had, and list some proteins which have the same functions with BAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptidase activity | GZME,METAP2B,CTSG,KLK1B26,PSMB9B,CTSL.1,HPN,AZU1,FOLH1,GM5077 |
| ubiquitin-specific protease activity | ATXN3L,USP6,FAM105B,OTUD4,CYLD,USP31,USP20,USP5,USP17L5,USP43 |
| chromatin binding | RAG2,SMC1A,PLAC8,ARID5A,LHX2,RERE,TADA2A,ZFP143,SOX14,ZMYND11 |
| protein binding | DEAF1,SILV,KCNJ5,SPRTN,SEC23IP,TEX19.1,SLBP,NUCB2,HIST1H4F,PIK3C2B |
Interacting Protein
BAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAP1.
ASXL1;HCFC1;BRCA1;UBA1;UBE2N;UBE2V1;Map3k1;IPO5;HAT1;OGT;PPM1G;ANKRD17;BRCA1
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References
- Onken, MD; Li, JM; et al. Uveal Melanoma Cells Utilize a Novel Route for Transendothelial Migration. PLOS ONE 9:-(2014).
- Castro, JMA; Oliveira, TS; et al. A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom. TOXICON 87:81-91(2014).
