BAK1

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  • Overview
  • Review / Q&A

  • Official Full Name

    BCL2-antagonist/killer 1

  • Overview

    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

  • Synonyms

    BAK1;BCL2-antagonist/killer 1;BAK;CDN1;BCL2L7;BAK-LIKE;bcl-2 homologous antagonist/killer;bcl2-L-7;BCL2-like 7 protein;bcl-2-like protein 7;apoptosis regulator BAK;pro-apoptotic protein BAK

Recombinant Proteins

  • Chicken
  • Human
  • Rhesus macaque
  • Mus musculus
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • E.coli
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
BAK1-2609C Recombinant Chicken BAK1 Mammalian Cells Chicken His
BAK1-26166TH Recombinant Human BAK1 Protein, GST-tagged Wheat Germ Human GST 1 a.a. - 211 a.a.
BAK1-26168TH Recombinant Human BAK1 Wheat Germ Human Non 112 amino acids
BAK1-509R Recombinant Rhesus monkey BAK1 Protein, His-tagged Mammalian Cells Rhesus macaque His
BAK1-8519HCL Recombinant Human BAK1 293 Cell Lysate HEK293 Human Non
BAK1-337R Recombinant Rhesus Macaque BAK1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
BAK1-337R-B Recombinant Rhesus Macaque BAK1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
BAK1-35H Recombinant Human BAK1 Protein, His-tagged E.coli Human His
RFL36987HF Recombinant Full Length Human Bcl-2 Homologous Antagonist/Killer(Bak1) Protein, His-Tagged E.coli Human His Full L. Full Length (1-211)
RFL9990MF Recombinant Full Length Mouse Bcl-2 Homologous Antagonist/Killer(Bak1) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-208)

Involved Pathway

BAK1 involved in several pathways and played different roles in them. We selected most pathways BAK1 participated on our site, such as Protein processing in endoplasmic reticulum,Viral carcinogenesis,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulum MAPK8A,HSC70,DNAJC5G,SVIP,SSR2,SAR1B,RAD23B,VIMP,MARCH6,PDIA6
MicroRNAs in cancer NOTCH4,IKBKB,WNT3,CCNE2,SERPINB5,HRAS,RPS6KA5,MAPK7,MTOR,TNC
Viral carcinogenesis HIST1H2BB,HIST1H4F,UBE3A,HIST2H4,SRF,GTF2H4,HDAC11,RBPJ,TRAF3,ACTN4

Protein Function

BAK1 has several biochemical functions, for example, BH domain binding,chaperone binding,heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAK1 itself. We selected most functions BAK1 had, and list some proteins which have the same functions with BAK1. You can find most of the proteins on our site.

Function Related Protein
BH domain binding Bcl2a1b,BCL2L2,BIK,BCL2A1A,BOK
identical protein binding PARP1,BNIPL,SDF4,SIRT1,MAP3K11,LRRK2,IFIT3,COL7A1,CLDN8,PKD2L1
metal ion binding SMYD4,HMOX2,HELZ2,KDM4D,ZFP580,MAP3K3,GEN1,ZNF446,GALNT12,ZNF219
protein heterodimerization activity TCF3A,CHRNA3,HIST2H4A,ARNT,RALGAPA2,ADIPOR2,SMC4,SYCP3,HIST2H2BE,UGT1A1
heat shock protein binding LMAN2,NFKBIA,DNAJA2,HSPA1B,DNAJC7,GPR37,DNAJA2L,DAXX,PDXP,PPP5C
ion channel binding KCNJ11,KCNE4,YWHAQ,KCNE1L,SLC14A2,PHPT1,FHL1,SLC8A1,KCNIP2,KCNQ3
chaperone binding SERPINA7,CDC37,TBCD,H2-KE2,VWF,TIMM9,TIMM10,CDC37L1,BAG4,UBL4A
protein binding ASCL4,BTF3L4,STRA13,MAP3K7IP3,RARS,NLRP2,Siglec1,PUS7L,CPT1B,NAA38
protein homodimerization activity DAPK3,ZNF174,NAGA,YARS2,CARD8,CBX1,TRIM37,RCHY1,SUMF1,CCBL1

Interacting Protein

BAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAK1.

MCL1;BCL2L1

Resources

Gene Families

What Is BCL2 Gene Family

Research Area

Bcl-2 Family

References

  • Lauf, PK; Alqahtani, T; et al. Interaction between Na-K-ATPase and Bcl-2 proteins BclXL and Bak. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308:C51-C60(2015).
  • Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).

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