ATP6V0D1
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Official Full Name
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -
Overview
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. -
Synonyms
ATP6V0D1;ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1;ATP6D, ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D , ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1 , ATPase, H+ transporting, lysosomal 38kDa,
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ATP6V0D1-10037H | Recombinant Human ATP, His-tagged | E.coli | Human | His | 1-351a.a. | |
| ATP6V0D1-1868H | Recombinant Human ATP6V0D1 protein, GST-tagged | E.coli | Human | GST | 1-351 aa | |
| ATP6V0D1-10021Z | Recombinant Zebrafish ATP6V0D1 | Mammalian Cell | Zebrafish | His |
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| ATP6V0D1-2154M | Recombinant Mouse ATP6V0D1 Protein | Mammalian Cell | Mouse | His |
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| ATP6V0D1-5584C | Recombinant Chicken ATP6V0D1 | Mammalian Cell | Chicken | His |
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| ATP6V0D1-997H | Recombinant Human ATP6V0D1 protein, GST-tagged | Wheat Germ | Human | GST |
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| ATP6V0D1-8588HCL | Recombinant Human ATP6V0D1 293 Cell Lysate | HEK293 | Human | Non |
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| ATP6V0D1-1091HF | Recombinant Full Length Human ATP6V0D1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 351 amino acids |
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| Atp6v0d1-672M | Recombinant Mouse Atp6v0d1 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ATP6V0D1-871M | Recombinant Mouse ATP6V0D1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ATP6V0D1-871M-B | Recombinant Mouse ATP6V0D1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ATP6V0D1 involved in several pathways and played different roles in them. We selected most pathways ATP6V0D1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0D1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rheumatoid arthritis | HLA-DRB4,FOS,ATP6V1E2,ATP6V0A1,IL23,CXCL6,TGFB2,TNFSF13B,ATP6V0E1,HLA-DRB5 |
| Metabolic pathways | IMPDH1A,SDHDB,CHSY1,ALDH1A1,MAT1A,DNMT1,MECR,LALBA,B3GNT5A,CMASA |
| Phagosome | RAC1A,ATP6V0C,TUBA7L,MHC2DEB,DYNC1I1,RAB5B,ATP6V1E1B,MARCO,NOX3,THBS1 |
| Vibrio cholerae infection | ACTG1,KDELR2,ATP6V0B,TJP1,ATP6V1G2,TJP2,ATP6V1F,GNAS,ATP6V1A,PRKACA |
| Synaptic vesicle cycle | ATP6V0E2,CPLX3,SNAP25,SYT1,ATP6V1A,ATP6V1E1,STX2,ATP6V0A2,SLC18A2,ATP6V0A4 |
| Oxidative phosphorylation | SDHB,COX5AA,NDUFS1,NDUFB3,NDUFA9A,ATP5J,ATP12A,SDHD,NDUFA3,COX6A2 |
| Viral carcinogenesis | PIK3CG,GTF2H3,GTF2H2C_2,HIST1H2BC,RHOA,HDAC4,TP53,BAK1,HIST1H4A,HDAC7A |
| Epithelial cell signaling in Helicobacter pylori infection | IKBKB,MAPK13,TJP1,JAM2,ATP6V1E1,ATP6V1H,ATP6V1C2,IKBKG,F11R,CDC42 |
| Lysosome | GALNS,LAMP3,CD164,SCARB2,AP1G2,MFSD8,ATP6AP1B,AP3B1,IDS,SORT1 |
Protein Function
ATP6V0D1 has several biochemical functions, for example, hydrogen-exporting ATPase activity, phosphorylative mechanism,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0D1 itself. We selected most functions ATP6V0D1 had, and list some proteins which have the same functions with ATP6V0D1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DUSP9,NANOS2,EGLN1,APBA3,SGIP1,CSE1L,SPTBN1,SPRY1,SPANXC,CD226 |
| protein complex binding | VDAC1,NASP,EP300,HTR2A,CRIPT,RANBP2,LCK,LZTFL1,MYO7A,KRT8 |
| hydrogen-exporting ATPase activity, phosphorylative mechanism | ATP6V1E2,ATP6V1C2,ATP6V1G1,ATP6V1C1,ATP6V1E1,ATP6V1G3 |
Interacting Protein
ATP6V0D1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0D1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0D1.
ATXN1;pi3p;Ccdc9;ATP6AP2;A2M;CDK1;PTPN1;Rab5c;Bmpr1a;TMPO;Vps4b;RAB5C;RAB7A;RAB2A;Cbx1;CLTC;Rmdn3;TMEM63B;Ptpn23;RFWD3
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References
- Pacheco-Costa, R; Hassan, I; et al. High Bone Mass in Mice Lacking Cx37 Because of Defective Osteoclast Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:8508-8520(2014).
- Chung, JY; Yi, JW; et al. Changes in Gene Expression in the Rat Hippocampus after Focal Cerebral Ischemia. JOURNAL OF KOREAN NEUROSURGICAL SOCIETY 50:173-178(2011).
