ATP6V0C
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Official Full Name
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -
Overview
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. -
Synonyms
ATP6V0C;ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c;ATP6C, ATP6L, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD , ATPL;V-type proton ATPase 16 kDa proteolipid subunit;VATL;Vma3;ATP6C;ATP6L;ATPase, H+ transporting, lysosomal, V0 subunit c;ATPL;V ATPase subunit c;Vacuolar ATP synthase 16 kDa proteolipid subunit;Vacuolar H+ ATPase proton channel subunit;Vacuolar proton pump, 16 kDa subunit;V-ATPase 16 kDa proteolipid subunit;vacuolar proton pump 16 kDa proteolipid subunit;H(+)-transporting two-sector ATPase, 16 kDa subunit;VPPC
Recombinant Proteins
- Chicken
- Rat
- Human
- Mouse
- Mus musculus
- Sheep
- Bovine
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- E.coli expression system
- His
- GST
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ATP6V0C involved in several pathways and played different roles in them. We selected most pathways ATP6V0C participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Collecting duct acid secretion | SLC4A1,ATP6V1A,ATP6V0A1,ATP6V1G1,ATP6V0E1,ATP4B,ATP6V1G3,SLC12A7,ATP6V1B1,ATP6V1E1 |
| Epithelial cell signaling in Helicobacter pylori infection | JAM2,ATP6V1H,ATP6AP1,CDC42,ATP6V1G2,MAPK10,SRC,MAP2K4,ATP6V1E1,ATP6V0A4 |
| Vibrio cholerae infection | ATP6V1C2,ATP6V1E1,MUC2,TJP2,ATP6V1D,ATP6V0B,ATP6V0D2,ATP6V1G2,KDELR2,TJP1 |
| Synaptic vesicle cycle | ATP6V0D2,STX1B,STX2,NSF,ATP6V0D1,SLC18A1,ATP6V1G2,DNM3,ATP6V1C2,ATP6V1B2 |
| Rheumatoid arthritis | HLA-DQA1,CD86,TGFB1,IL-8,HLA-DQA2,Il23a; Il12b,ATP6V0E,MMP3,CCL3,ICAM1 |
| Phagosome | TUBA1A,TUBA1B,C1R,ATP6V1B1,SEC61G,SEC22BB,DYNC1LI2,THBS4B,MHC2DAB,CTSSB.1 |
| Tuberculosis | FCGR3B,SRC,ITGB2L,NFYC,IFNA12,HLA-DRB3,IFNA21,CALM2,MAPK13,APAF1 |
| Metabolic pathways | PDHA1,GKUP,GLUL,CEL.1,PCXB,ATP6V1C2,NDUFC1,PNP,NT5C1AA,CMBL |
| Lysosome | CTSSA,GGA1,SLC11A2,GUSB,AP3D1,DNASE2B,NEU1,CLTCB,Abca2,SGSH |
Protein Function
ATP6V0C has several biochemical functions, for example, protein binding,proton-transporting ATP synthase activity, rotational mechanism,proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0C itself. We selected most functions ATP6V0C had, and list some proteins which have the same functions with ATP6V0C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | SCN5A,DERL1,TUBB,TUBA1B,PIAS1,POLR2A,UBE2H,TMEM189,JKAMP,BCL10 |
| proton-transporting ATPase activity, rotational mechanism | ATPV0E2,ATP6V0E,ATP5E,ATP6V0CA,ATP6V1E2,ATP5B,ATP6V1C1,ATP6V0CB,ATP6V0A4,ATP6V1H |
| proton-transporting ATP synthase activity, rotational mechanism | ATP5O,ATP5C1,ATP5E,ATP6AP1B,ATP5A1,ATP6AP1,ATP5B |
| protein binding | CDK15,MAPRE1,C6,ZNF276,ACACB,GNG10,UCHL3,CAMLG,MC4R,MTMR6 |
Interacting Protein
ATP6V0C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0C here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0C.
CERS2;MSR1;PSMA3;EDA;SMIM3;PDGFRB;E5;CLIC1;MARK3
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References
- Mangieri, LR; Mader, BJ; et al. ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease. PLOS ONE 9:-(2014).
- Pavelin, J; Reynolds, N; et al. Systematic MicroRNA Analysis Identifies ATP6V0C as an Essential Host Factor for Human Cytomegalovirus Replication. PLOS PATHOGENS 9:-(2013).
