ATP1A3
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Official Full Name
ATPase, Na+/K+ transporting, alpha 3 polypeptide -
Overview
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of;Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the;electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for;osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical;excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a;smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene;encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for;this gene. -
Synonyms
ATP1A3;ATPase, Na+/K+ transporting, alpha 3 polypeptide;dystonia 12 , DYT12;sodium/potassium-transporting ATPase subunit alpha-3;Alpha(III);AT1A3_HUMAN;ATPase Na+/K+ transporting alpha 3 polypeptide;DYT 12;DYT12;MGC13276;Na(+)/K(+) ATPase alpha(III) subunit;Na(+)/K(+) ATPase alpha-3 subunit;Na+/K+ ATPase 3;Na+/K+ ATPase alpha 3 subunit;RDP;Sodium potassium ATPase alpha 3 polypeptide;Sodium pump 3;Sodium pump subunit alpha-3;Sodium/potassium transporting ATPase alpha 3 chain;sodium-potassium-ATPase, alpha 3 polypeptide;sodium/potassium-transporting ATPase alpha-3 chain
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
ATP1A3 involved in several pathways and played different roles in them. We selected most pathways ATP1A3 participated on our site, such as cGMP-PKG signaling pathway,cAMP signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cardiac muscle contraction | CACNB3A,CACNB2,CACNA1SB,TPM4B,UQCRC2A,CACNB2A,CACNG7A,COX8C,COX8A,ATP1B3A |
| Gastric acid secretion | KCNJ1,PLCB4,CALML3,CA2,PRKACG,KCNJ2,HRH2,GNAQ,GNAS,CALML5 |
| Pancreatic secretion | CLCA3,PLCB1,CLCA2,RYR2,SCTR,CLCA5,AMY2A,PLCB3,TRPC1,CPA2 |
| Adrenergic signaling in cardiomyocytes | PPP2R5B,PPP2R5D,ATP2A2,PRKACBB,CACNG6A,CALM1A,ADRB1,CREM,TPM4,TPM3 |
| cGMP-PKG signaling pathway | MAPK1,ATP2A1,ROCK2,INS2,PPIF,MAP2K2,GNAQ,AKT1,NFATC4,SLC25A31 |
| Protein digestion and absorption | COL15A1,FXYD2,SLC3A1,CPA3,PGA5,SLC36A1,KCNQ1,COL13A1,CTRL,LOC780933 |
| Insulin secretion | ATP1A2,KCNMB1,ATP1B3,CREB5,RYR2,GNAQ,PDX1,ADCYAP1,TRPM4,RIMS2 |
| Bile secretion | NCEH1,SLC9A1,ADCY6,ADCY7,SLCO1A5,PRKACA,SLC51A,ABCB1A,SLCO1A2,ABCC2 |
| Aldosterone-regulated sodium reabsorption | ATP1B4,PDPK1,INSR,SCNN1B,PIK3CB,INS2,IRS1,SCNN1G,FXYD4,PRKCB |
Protein Function
ATP1A3 has several biochemical functions, for example, ATP binding,D1 dopamine receptor binding,chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A3 itself. We selected most functions ATP1A3 had, and list some proteins which have the same functions with ATP1A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SMARCA2,EARS2,ABCB3L1,DYNC2H1,PIP4K2A,PDGFRB,ABCA8,MTHFS,RPS6KB2,AKT3A |
| steroid hormone binding | GPR30,NR3C1,ESR2B,ESR2A,ATP1A1,ATP1A2 |
| chaperone binding | AMFR,TG,BAG5,TP53,SYVN1,ERP29,PARK2,DNAJA4,BIRC5,DNAJA3B |
| sodium:potassium-exchanging ATPase activity | ATP1A1,ATP1A3B,ATP1A1A.2,ATP1A2,ATP1B3,ATP1A3A,ATP1A1A.1,FXYD2,ATP1A1A.3,ATP1A2A |
| D1 dopamine receptor binding | AGTR1A,PTPN11,DLG4,ARRB2,GNAS,CAV2,DRD3 |
| metal ion binding | CNOT7,NRP1,METAP2A,MBLAC2,TKTL2,CD209B,PNLIP,PDLIM5B,TNNI3,ZNF511 |
Interacting Protein
ATP1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A3.
PCBD1;ATXN1;CASP8;15-deoxy-delta(12,14;a52_vaccw;AGO2
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References
- Murakami, Y; Ikeda, U; et al. Promoter of the Na,K-ATPase alpha 3 subunit gene is composed of cis elements to which NF-Y and Sp1/Sp3 bind in rat cardiocytes. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1352:311-324(1997).
