ATG5
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Official Full Name
autophagy related 5 -
Overview
Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed.<br/>May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. -
Synonyms
ATG5;autophagy related 5;ASP;APG5;APG5L;hAPG5;APG5-LIKE;autophagy protein 5;apoptosis-specific protein;ATG5 autophagy related 5 homolog
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ATG5 involved in several pathways and played different roles in them. We selected most pathways ATG5 participated on our site, such as Regulation of autophagy,RIG-I-like receptor signaling pathway,Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATG5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of autophagy | IFNA5,GABARAP,ATG16L1,IFNA12,ATG12,ATG13,IFNG1-2,IFNPHI3,GABARAPL1,IFNA10 |
| Shigellosis | SRC,WAS,MAPK9,MAD2L2,RELA,FBXW11,RAC1,VCL,MAPK12,WASF1 |
| RIG-I-like receptor signaling pathway | IFNB,SIKE1,IFNA6,IFNA5,IKBKG,CXCL10,CASP8,IFNA10,DDX3,DDX3X |
Protein Function
ATG5 has several biochemical functions, for example, contributes_to Atg8 ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATG5 itself. We selected most functions ATG5 had, and list some proteins which have the same functions with ATG5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SNRPD1,RFPL3,TMEM30B,SGCA,SUGT1,MCM10,ZMAT2,RABAC1,TRAF4,PTPN11 |
Interacting Protein
ATG5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATG5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATG5.
ATG12;WDFY3;ATG16L1;GABARAP;MAP1LC3B
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References
- Cai, PP; Wang, HX; et al. Variants of autophagy-related gene 5 are associated with neuromyelitis optica in the Southern Han Chinese population. AUTOIMMUNITY 47:563-566(2014).
- Cenci, S; et al. Autophagy, a new determinant of plasma cell differentiation and antibody responses. MOLECULAR IMMUNOLOGY 62:289-295(2014).
