ATG4A
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Official Full Name
ATG4 autophagy related 4 homolog A -
Overview
Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Control of autophagy was largely discovered in yeast and involves proteins encoded by a set of autophagy-related genes (Atg) (1). Formation of auto -
Synonyms
ATG4A;ATG4 autophagy related 4 homolog A (S. cerevisiae);APG4 autophagy 4 homolog A (S. cerevisiae) , APG4A, AUT like 2, cysteine endopeptidase (S. cerevisiae) , AUTL2;cysteine protease ATG4A;hAPG4A;autophagin 2;autophagin-2;APG4 autophagy 4 homol
Recombinant Proteins
- Zebrafish
- Human
- Rhesus macaque
- Chicken
- Mammalian Cell
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- E. coli
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ATG4A-3034Z | Recombinant Zebrafish ATG4A | Mammalian Cell | Zebrafish | His |
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| ATG4A-36H | Recombinant Human ATG4A, His-tagged | E.coli | Human | His | 1-398 a.a. |
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| ATG4A-441R | Recombinant Rhesus monkey ATG4A Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ATG4A-4695C | Recombinant Chicken ATG4A | Mammalian Cell | Chicken | His |
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| ATG4A-4696C | Recombinant Chicken ATG4A | Mammalian Cell | Chicken | His |
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| ATG4A-948H | Recombinant Human ATG4A protein, GST-tagged | Wheat Germ | Human | GST |
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| ATG4A-1512HF | Recombinant Full Length Human ATG4A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 398 amino acids |
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| ATG4A-270R | Recombinant Rhesus Macaque ATG4A Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ATG4A-270R-B | Recombinant Rhesus Macaque ATG4A Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| ATG4A-6522H | Recombinant Human ATG4A protein, His-tagged | E. coli | Human | His | 413aa(including fusion tag) |
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Involved Pathway
ATG4A involved in several pathways and played different roles in them. We selected most pathways ATG4A participated on our site, such as Cellular responses to stress,Macroautophagy,Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATG4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Macroautophagy | MAP1LC3B,UVRAG,ATG9A,RB1CC1,GABARAPL2,GABARAP,WDR45,DYNLL2A,WDR45L,AMBRA1A |
| Regulation of autophagy | INS,ULK3,IFNA4,IFNPHI3,IFNA7,IFNA13,IFNA12,Ifna11,INS2,ATG5 |
| Cellular responses to stress | HSBP1B,AMBRA1B,RING1,HSBP1,H3F3D,POT1,SCMH1,ATG9A,HIST2H3C,HIST1H1D |
Protein Function
ATG4A has several biochemical functions, for example, cysteine-type endopeptidase activity,cysteine-type peptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATG4A itself. We selected most functions ATG4A had, and list some proteins which have the same functions with ATG4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type peptidase activity | CASPA,CTSC,CAPN3A,USPL1,CASP3A,OTUD7A,CTSL1B,SENP8,CAPN2,CAPN12 |
| protein binding | TSSK6,DYRK1A,DRG1,VPS37B,RBM12B,OTUB2,SPAG5,C1QA,SIGLEC6,HIST4H4 |
| cysteine-type endopeptidase activity | PDIA3,USP25,USP40,CTSSB.1,CASPB,CTSL1,Ctsl,CASP9,CTSJ,USP38 |
Interacting Protein
ATG4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATG4A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATG4A.
CDKL3;GABARAPL1;MAP1LC3B;SYN1;PDK1;USP43;THOC1;NUF2;MAP1LC3A
Resources
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References
- Fan, JD; Lei, PJ; et al. The Selective Activation of p53 Target Genes Regulated by SMYD2 in BIX-01294 Induced Autophagy-Related Cell Death. PLOS ONE 10:-(2015).
- Liao, YP; Chen, LY; et al. Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients. HUMAN MOLECULAR GENETICS 23:1894-1906(2014).
