ATG10
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Official Full Name
autophagy related 10 -
Overview
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008] -
Synonyms
ATG10;autophagy related 10;APG10;APG10L;pp12616;ubiquitin-like-conjugating enzyme ATG10;autophagy-related protein 10;ATG10 autophagy related 10 homolog
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
ATG10 involved in several pathways and played different roles in them. We selected most pathways ATG10 participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATG10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of autophagy | INS2,PRKAA2,IFNPHI1,ATG13,ATG12,PIK3C3,ULK3,IFNA12,IFNPHI3,GABARAPL1 |
Protein Function
ATG10 has several biochemical functions, for example, Atg12 transferase activity,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATG10 itself. We selected most functions ATG10 had, and list some proteins which have the same functions with ATG10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Atg12 transferase activity | ATG3 |
| ligase activity | SMURF1,MARCH6,SIAH2,RNF19B,UBE2L3B,ARIH1,ACSM2,CPS1,UBE3B,CBLL1 |
Interacting Protein
ATG10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATG10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATG10.
GABARAP;GABARAPL2;MAP1LC3C;MAP1LC3B;GABARAPL1;MAP1LC3B2;HAT1;ATG12;ATG7;MAP1B;USP11;RBBP7;USP7;ATG3;ATG4B;q81sn0_bacan
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References
- Pulliero, A; Seydel, A; et al. Oxidative Damage and Autophagy in the Human Trabecular Meshwork as Related with Ageing. PLOS ONE 9:-(2014).
- Zhang, LS; Zhang, J; et al. Autophagy in Pancreatic Acinar Cells in Caerulein-treated Mice: Immunolocalization of Related Proteins and Their Potential as Markers of Pancreatitis. TOXICOLOGIC PATHOLOGY 42:435-457(2014).
