ATF6
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Official Full Name
activating transcription factor 6 -
Overview
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] -
Synonyms
ATF6;activating transcription factor 6;ATF6A;cyclic AMP-dependent transcription factor ATF-6 alpha;cAMP-dependent transcription factor ATF-6 alpha
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- His&T7
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
ATF6 involved in several pathways and played different roles in them. We selected most pathways ATF6 participated on our site, such as Protein processing in endoplasmic reticulum,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | ATF4,HSP90AA1.2,BCL2A,EDEM1,ERO1LB,WFS1,SEL1L,UBE2J2,RBX1,UBE2D1A |
| Alzheimers disease | NDUFB4,SDHB,IL1B2,NDUFA5,ATP5G3,IDE,UQCRB,PLCB1,PPP3CC,GRIN2A |
Protein Function
ATF6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,cAMP response element binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATF6 itself. We selected most functions ATF6 had, and list some proteins which have the same functions with ATF6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | ARNT,ADRA1B,KCNA3,BOKA,BMP2,H2AFV,ATF1,KCNK3,MEF2C,CYBA |
| transcription factor activity, sequence-specific DNA binding | KLF2,HOMEZ,FOXC1,ZNF544,ATF7A,LCOR,FOXH1,GRHL2,PBX1,ZNF45 |
| protein binding | FAH,TCEB3,TACC3,CD84,AHNAK2,TAF1C,EFCAB4A,PTPN23,IRF4,FEZ1 |
| cAMP response element binding | JUN,ATF2,CREB3,E4F1,CREB3L1,ATF6B,CREB3L3,CREB3L2,CREB3L3L,HMGA2 |
| transcription coactivator activity | PCBD1,PIAS2,MTF1,SOX10,GATA3,TFDP1A,POU2AF1,WNT3A,ACTL6A,IL31RA |
| RNA polymerase II regulatory region sequence-specific DNA binding | ATF4B1,E2F7,PCGF6,CREBBP,HOXD8,MEF2C,ZFP583,BARHL1B,ZIK1,DBP |
Interacting Protein
ATF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATF6.
CREB3L3;XBP1;Klc2;BPGM;CREB1;TNFRSF1A;DDC;p27958-pro_0000037575;NNMT;BALF4 (provisional);NFYC;dppA;papC;fhuB;q8d1i7_yerpe;y1009_yerpe
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References
- Wang, JJ; Cheng, QY; et al. Deficiency of IRE1 and PERK Signal Pathways in Systemic Lupus Erythematosus. AMERICAN JOURNAL OF THE MEDICAL SCIENCES 348:465-473(2014).
- Park, KS; Bayles, I; et al. Transcription Elongation Factor ELL2 Drives Ig Secretory-Specific mRNA Production and the Unfolded Protein Response. JOURNAL OF IMMUNOLOGY 193:4663-4674(2014).
