ASB11
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Official Full Name
ankyrin repeat and SOCS box containing 11 -
Overview
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ASB11;ankyrin repeat and SOCS box containing 11;ankyrin repeat and SOCS box protein 11;DKFZp779E2460;ASB-11;ankyrin repeat domain-containing SOCS box protein ASB11;MGC119168;MGC119169
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- His
- GST
- His&Fc&Avi
- His&SUMO
Involved Pathway
ASB11 involved in several pathways and played different roles in them. We selected most pathways ASB11 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASB11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome degradation | SPSB1,LRR1,ASB4,RNF34,UBE2F,LRRC41,IWS1,WSB1,VPRBP,ASB3 |
| Class I MHC mediated antigen processing & | SPSB1,UBE2L6,CTSS,TRIM69,CD207,FCGR1B,SPSB2,ASB9,RNF6,CMTM2A |
| presentation | MKRN1,PJA2,TRIM11,RNF144B,ERAP1,TRIM41,CMTM2A,BLMH,FBXO3,ASB6 |
| Immune System | CD200R3,NCKAP1,UBE2J2,KIFAP3,AF251705,RNF216,OSCAR,BTR22,BTR02,HUWE1 |
| Adaptive Immune System | LILRB3,STUB1,FRS2,UBE2J2,GAN,DYNC1I1,LILRB2,GRAP2B,SIGLEC10,CD160 |
| Antigen processing: Ubiquitination & | UBE2L6,ASB14,ASB17,RNF123,CMTM2A,ASB2,LTN1,ASB4,UBE2F,SPSB4 |
Protein Function
ASB11 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ASB11 itself. We selected most functions ASB11 had, and list some proteins which have the same functions with ASB11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | EMC3,MARCH9,LAGE3,PODNL1,FAM117A,TMEM91,AAR2,TMEM225,NDRG4,CEP19 |
Interacting Protein
ASB11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASB11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASB11.
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References
- Fingert, JH; Roos, BR; et al. Analysis of ASB10 variants in open angle glaucoma. HUMAN MOLECULAR GENETICS 21:4543-4548(2012).
- da Silva, MAS; Tee, JM; et al. Essential Role for the d-Asb11 cul5 Box Domain for Proper Notch Signaling and Neural Cell Fate Decisions In Vivo. PLOS ONE 5:-(2010).
