ARHGEF2
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Official Full Name
Rho/Rac guanine nucleotide exchange factor (GEF) 2 -
Overview
Rho family small GTPases regulate processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP. GEF-H1 is a Rho GEF that localiz -
Synonyms
ARHGEF2;Rho/Rac guanine nucleotide exchange factor (GEF) 2;rho guanine nucleotide exchange factor 2;GEF H1;KIAA0651;LFP40;P40;microtubule-regulated Rho-GEF;guanine nucleotide exchange factor H1
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ARHGEF2 involved in several pathways and played different roles in them. We selected most pathways ARHGEF2 participated on our site, such as Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathogenic Escherichia coli infection | TUBA3D,TUBA1B,CD14,EZR,TUBA8,CDC42,TUBA3E,ABL1,KRT18,TUBB1 |
Protein Function
ARHGEF2 has several biochemical functions, for example, Rac GTPase binding,Rac guanyl-nucleotide exchange factor activity,Rho GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF2 itself. We selected most functions ARHGEF2 had, and list some proteins which have the same functions with ARHGEF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rac GTPase binding | RAB7A,OCRL,RALBP1,PKN1,ARHGAP4A,ARHGAP4,RCC2,SRGAP2,PAK4,SRGAP2A |
| microtubule binding | UXT,TRAF3IP1,DYNC1I1,SKA1,SNCA,JAKMIP3,POLB,MTUS2,MAPRE1B,CEP57L1 |
| transcription factor binding | FOXA3,C1QBP,CEBPA,RNF19A,NBN,KCTD1,KAT8,FOXA2,MYOD1,GTF2A1 |
| zinc ion binding | PEX12,FTR50,PHC2,DPEP1,UBR1,ADAM25,RXRGA,CPM,PGLYRP2,ADA |
| Rho GTPase binding | AKAP13,CSDA,IQGAP3,ROCK2A,ROCK2,DIAP1,PFN1,CDC42BPB,INF2,DIAP3 |
| Rho guanyl-nucleotide exchange factor activity | FGD4A,QUO,ARHGEF17,ARHGEF1A,ARHGEF37,ARHGEF3,FGD6,C3A.1,VAV3,PLEKHG7 |
| protein binding | EDNRB,RAB22A,SYNJ2BP,TCL1A,TMEM106B,UBE2F,PCTP,TCTEX1D1,MAL2,TRAF2 |
| Rac guanyl-nucleotide exchange factor activity | SPATA13,ALS2,DOCK2,PREX2,ARHGEF4,VAV1,FARP1,VAV3,FARP2 |
Interacting Protein
ARHGEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF2.
YWHAG;MYC;YWHAZ;RPP25L;ANKRD28;NFKBIE;PAK4;MARK2;KSR1;q81ql4_bacan;pi3p;15-deoxy-delta(12,14;ssrna_ug
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References
- Zheng, ZL; Liebers, M; et al. Anchored multiplex FOR for targeted next-generation sequencing. NATURE MEDICINE 20:1479-1484(2014).
- Huang, IH; Hsiao, CT; et al. GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment. JOURNAL OF CELL SCIENCE 127:4186-4200(2014).
