ARAF
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Official Full Name
v-raf murine sarcoma 3611 viral oncogene homolog -
Overview
A-Raf, B-Raf and c-Raf (Raf-1) are the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. Activation of c-Raf is the best understood and involves phosphorylation at multiple activating sites including Ser338, Tyr341, Thr491, -
Synonyms
ARAF;v-raf murine sarcoma 3611 viral oncogene homolog;ARAF1, v raf murine sarcoma 3611 viral oncogene homolog 1;serine/threonine-protein kinase A-Raf;Oncogene ARAF1;proto-oncogene Pks;proto-oncogene A-Raf-1;Ras-binding protein DA-Raf;v-raf murine
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- DDK
- Myc
- Non
- Avi
- Fc
- Flag
Involved Pathway
ARAF involved in several pathways and played different roles in them. We selected most pathways ARAF participated on our site, such as ErbB signaling pathway,FoxO signaling pathway,Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endometrial cancer | TCF7L2,CCND1,GSK3B,BRAF,MAP2K2,CDH1,HRAS,ERBB2,KRAS,AKT2 |
| Bladder cancer | FGFR3,MMP1,MAPK3,E2F1,HRAS,MMP2,RASSF1,EGF,MMP1A,MAP2K2 |
| Regulation of Actin Cytoskeleton | ITGA6,MYL7,FGFR2,INS2,PPP1CB,PIK3R3,RHOA,TMSB4Y,RAC1B,FGF1A |
| Acute myeloid leukemia | ZBTB16,AKT2,MYC,CCNA1,TCF7L2,CEBPA,NRAS,MAPK1,KRAS,PIK3CA |
| Non-small cell lung cancer | RAF1,RXRG,FOXO3,PLCG1,PIK3CG,NRAS,ALK,MAPK1,AKT1,SOS1 |
| Pancreatic cancer | IKBKG,NFKB1,RAC2,RALBP1,RALB,ARHGEF6,MAPK1,BCL2L1,MAPK3,CASP9 |
| Renal cell carcinoma | RAC1,PAK2,FH1,FH,MAPK1,RAP1B,VEGFA,PIK3CA,PTPN11,AHA-1 |
| Vascular smooth muscle contraction | GNAQ,PLA2G2E,PLA2G1B,CACNA1D,CALM1B,PRKCH,RAF1B,PRKACA,PLA2G4AA,CACNA1C |
| Natural killer cell mediated cytotoxicity | Raet1a,HLA-G,FYN,TNFRSF10C,NRAS,SH3BP2,SOS1,PPP3CC,PRKCB,ITGB2 |
Protein Function
ARAF has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAF itself. We selected most functions ARAF had, and list some proteins which have the same functions with ARAF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | MOCS1,POGZ,ATP2B1A,PVALB6,NME7,ITGB1,ATF2,ASH2L,MBLAC2,FAM164C |
| ATP binding | ABCC8,CCT7,FLT1,TUT1,RET,SGK2B,TAP1,EPHA3,KIF4,UCK1 |
| protein binding | ZCCHC12,NUAK1,EIF4B,POLH,BAZ2A,DOHH,MUSK,ISOC2,HJURP,PRKAB2 |
| protein serine/threonine kinase activity | UHMK1,ACVR2A,IRAK1,NLK2,HIPK2,IKBKB,TTBK2,RIOK2,TRIO,AAK1 |
| receptor signaling protein activity | DCLK1,RGS14A,NCR1,DOK5,FCAR,TGFBR1,FLRT1,NSMAF,TIAM2,RAF1A |
| protein kinase activity | TGFBR1B,FYNB,EPHA4A,PRPF4B,STK26,NAT1,VRK1,IRAK1,STK25,CCL3 |
Interacting Protein
ARAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAF here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAF.
MAP2K2;YWHAZ;HSP90AB1;YWHAG
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References
- Sumiyoshi, M; Nakamura, A; et al. Increase in Cellulose Accumulation and Improvement of Saccharification by Overexpression of Arabinofuranosidase in Rice. PLOS ONE 8:-(2013).
- Yu, L; Yu, CJ; et al. Structural analysis of galactoarabinan from duckweed. CARBOHYDRATE POLYMERS 117:807-812(2015).
