AP1B1
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Official Full Name
adaptor-related protein complex 1, beta 1 subunit -
Overview
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. -
Synonyms
AP1B1;adaptor-related protein complex 1, beta 1 subunit;ADTB1, CLAPB2;AP-1 complex subunit beta-1;AP105A;BAM22;beta1-adaptin;beta-1-adaptin;beta-adaptin 1;beta-prime-adaptin;Golgi adaptor HA1/AP1 adaptin beta subunit;adaptor protein complex AP-
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- E.Coli or Yeast
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- HEK293T
- HEK293
- His
- GST
- Myc&DDK
- His&Fc&Avi
- His&Myc
Involved Pathway
AP1B1 involved in several pathways and played different roles in them. We selected most pathways AP1B1 participated on our site, such as Adaptive Immune System,Clathrin derived vesicle budding,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Golgi Associated Vesicle Biogenesis | PPIAL4A,PICALMB,NECAP1,NAPAA,SNX9A,SNAPIN,AP1M2,HIP1RB,NAPAB,HIP1R |
| FOXA1 transcription factor network | FOXA1,NRIP1,CC10,TFF1,CEBPB,NR2F2,NFIA,POU2F1,CYP2C18,NFIB |
| Disease | CCNC,AP2B1,TRIM24,TTR,MMADHC,TIRAP,GYG1,JAG2,RBP1,AP2A2 |
| HIV Infection | RCC1,AP1G1,NMT1,PDCD6IP,CDK9,TAF1L,PACS1,DOCK2,PSTPIP2,AP1S1 |
| Immune System | TCIRG1,GM11711,ASB4,CTSO,LAIR2,KIF15,TRIM9,TRIM10,RAP1GAP2B,PPAPDC1B |
| Host Interactions of HIV factors | APOBEC3G,PPIAL4A,AP1S1,PACS1,AP1G1,DOCK2,PSIP1,RCC1,AP1M2 |
| Adaptive Immune System | CTSC,PIK3AP1,B2ML,MKRN1,NRG3,KLHL21,HCST,CYBB,UBA5,UBE2L6 |
| Clathrin derived vesicle budding | BLOC1S1,SNX9A,SNAPIN,TBC1D8B,AP4B1,PICALMA,TPD52,BLOC1S3,NAPAA,BLOC1S6 |
Protein Function
AP1B1 has several biochemical functions, for example, protein binding,protein kinase binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP1B1 itself. We selected most functions AP1B1 had, and list some proteins which have the same functions with AP1B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transporter activity | TMEM184BA,FABP1B.1,PTGDSA,ABCA6,AQP9B,FABP5,FABP11A,ATP5G3,VPS9D1,STEAP2 |
| protein transporter activity | ZFYVE16,AP1S3B,AP2A2,FRAG1,AP4S1,RAB4A,AP2B1,CALCRL,IPO4,TNPO1 |
| protein binding | SUCLA2,PSMD11,IMPA1,HOMEZ,ESYT1,FAM59A,NDP,SID4,INIP,TRPS1 |
| protein kinase binding | BCAR1,CCNL1A,PRKACA,CDKN2B,HSPB1,IL12RB2,CHRNA7,TRIM5,LIMS1,TTN |
Interacting Protein
AP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP1B1.
Ap1g1;Ap1m1;nef;AP1S1;AP1S3;1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate
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References
- Saito, T; Ji, G; et al. Genetic variations in humans associated with differences in the course of hepatitis C. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 317:335-341(2004).
