AMACR
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Official Full Name
alpha-methylacyl-CoA racemase -
Overview
P504S is an enzyme involved in the β-oxidation of branched-chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It has also been found to stain premalignant lesions of the prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN. It may be useful to confirm the diagnosis of small foci of prostate carcinoma in needle biopsies. P504S stains the majority prostate cancer, however, P504S has been shown to stain many other types of carcinoma such as hepatoma, breast carcinoma, pancreatic islet tumor and desmoplastic small round cell tumor (Miller and Tacha)1. HMW CK and p63 may serve as a useful panel. -
Synonyms
AMACR;alpha-methylacyl-CoA racemase;RM;RACE;CBAS4;AMACRD;2-methylacyl-CoA racemase;OTTHUMP00000115916;OTTHUMP00000115917;OTTHUMP00000219978;TTHUMP00000219979;TTHUMP00000219980;EC 5.1.99.4;P504S
Recombinant Proteins
- Human
- Mouse
- human
- Chicken
- Rhesus macaque
- Wheat Germ
- E.coli
- HEK293
- Mammalian Cell
- N/A
- E.Coli or Yeast
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- Non
- Myc&DDK
- His
- His&Fc&Avi
- Flag
Involved Pathway
AMACR involved in several pathways and played different roles in them. We selected most pathways AMACR participated on our site, such as Primary bile acid biosynthesis,Metabolic pathways,Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMACR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Primary bile acid biosynthesis | CYP46A1,CYP7B1,CH25HL2,CYP46A1.4,CYP39A1,BAAT,SCP2,SCP2A,CYP8B1,CYP7A1A |
| Peroxisome | ACSL1B,ACOX3,PXMP4,ANI_1_2390104,PEX2,NUDT7,PIPOX,ACSL5,ACOX2,DAO.2 |
| Metabolic pathways | RIMKLA,PLCD4,ALDH4A1,LDHC,PIP5K1B,ALG12,UCKL1,GLCEB,HMGCS1,LDHAL6A |
Protein Function
AMACR has several biochemical functions, for example, alpha-methylacyl-CoA racemase activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMACR itself. We selected most functions AMACR had, and list some proteins which have the same functions with AMACR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | PVRL3B,Fert2,PLAT,RASA1,GSTM7,HSD17B4,Artn,CXADR,CADM1B,LPL |
Interacting Protein
AMACR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMACR here. Most of them are supplied by our site. Hope this information will be useful for your research of AMACR.
Resources
Research Area
Fatty Acid CatabolismOvarian Cancer Stem Cell Markers
Prostate Cancer Stem Cell Markers
Cancer Biomarkers in Clinical Practice
Prostate Cancer Biomarkers
Related Services
Related Products
References
- He, JT; Schepmoes, AA; et al. Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods. JOURNAL OF TRANSLATIONAL MEDICINE 13:-(2015).
- McDaniel, AS; Chinnaiyan, AM; et al. Immunohistochemical Staining Characteristics of Nephrogenic Adenoma Using the PIN-4 Cocktail (p63, AMACR, and CK903) and GATA-3. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:1664-1671(2014).
