ALKBH1
-
Official Full Name
alkB, alkylation repair homolog 1 -
Overview
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. -
Synonyms
ALKBH1;alkB, alkylation repair homolog 1 (E. coli);alkB, alkylation repair homolog (E. coli) , ALKBH;alkylated DNA repair protein alkB homolog 1;ABH;alkB;hABH;DNA lyase ABH1;alkylation repair, alkB homolog;alpha-ketoglutarate-dependent dioxygenas
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Wheat Germ
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
ALKBH1 involved in several pathways and played different roles in them. We selected most pathways ALKBH1 participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Integrated Breast Cancer Pathway | DHTKD1,NOXA1,PLK3,APOBEC3G,LGALS13,NAB1,CCNB1IP1,USP16,GRN,RPP38 |
Protein Function
ALKBH1 has several biochemical functions, for example, DNA-(apurinic or apyrimidinic site) lyase activity,ferrous iron binding,methylcytosine dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH1 itself. We selected most functions ALKBH1 had, and list some proteins which have the same functions with ALKBH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-(apurinic or apyrimidinic site) lyase activity | NEIL2,NEIL3,HMGA1-RS1,HMGA2,NEIL1,HMGA1B,APLF,HMGA1A,NTHL1,APEX1 |
| ferrous iron binding | ALKBH3,BCO1,NT5E,TH,ALKBH2,ACP5,UROD,TET2,SNCA,DNAJC24 |
| methylcytosine dioxygenase activity | TET2,TET3,TET1 |
Interacting Protein
ALKBH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH1.
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