ALDOB
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Official Full Name
aldolase B, fructose-bisphosphate -
Overview
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related housekeeping genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. -
Synonyms
ALDOB;aldolase B, fructose-bisphosphate;fructose-bisphosphate aldolase B;ALDB;ALDO B;ALDOB_HUMAN;Aldolase 2;Aldolase B;Aldolase B fructose bisphosphate;Aldolase2;AldolaseB;EC 4.1.2.13;Fructose bisphosphate aldolase B;Liver type aldolase;Liver-type aldolase;OTTHUMP00000021803;OTTHUMP00000021804;aldolase B, fructose-bisphosphatase;ALDO2
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rabbit
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Myc&DDK
- His&SUMO
Involved Pathway
ALDOB involved in several pathways and played different roles in them. We selected most pathways ALDOB participated on our site, such as Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fructose and mannose metabolism | HK3,AKR1B1,PFKFB2A,PFKFB1,PFKMA,FBP1,FBP1B,DHRS13L1,TIGARB,ALDOAA |
| Metabolic pathways | GAD2,GALNT2,EXT1A,PLCB1,BDH1,ALOX12,INPP1,MTMR3,GNE,FUT9A |
| Glycolysis / Gluconeogenesis | HK1,PGAM2,G6PCA.2,ADH1,ALDH3A1,FBP2,GPI,PDHA1,PGAM1A,PDHA1A |
| Carbon metabolism | PDHA2,PRPS1,HADHAB,MUT,PFKMB,TPI1,DLDH,GPT2L,AGXTA,PFKL |
| Pentose phosphate pathway | PRPS2,GPI,GPIB,PFKM,PRPS1,PFKMA,RGN,RBKS,TKTL2,ALDOAA |
| Biosynthesis of amino acids | PFKMA,ALDOC,MAT2B,ACY1,PKM2,TPI1,ASL2,GLUL,PKLR,TALDO1 |
Protein Function
ALDOB has several biochemical functions, for example, ATPase binding,cytoskeletal protein binding,fructose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDOB itself. We selected most functions ALDOB had, and list some proteins which have the same functions with ALDOB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | APOE,GRIN3A,KCNH2,HSD17B10,ADORA2A,VIM,OMG,RABAC1,PARK2,APLP1 |
| ATPase binding | SLN,ANK1,GRIN2A,NSFL1C,ATP6V0A4,TOR1AIP1,DRD1A,PEX19,WFS1,SNTA1 |
| fructose-bisphosphate aldolase activity | ALDOA,ALDOC,ALDOAA,ALDOCB,ALDOCA,ALDOAB |
| protein binding | KRT40,ZNF266,ELP3,MICA,JAK1,AMMECR1,GNAI2,CFL1,MIA3,GYG1 |
| phosphatidylcholine binding | APOA4B.2,SERPINA5,PCTP,APOA4A,APOC1,VPS24,RPE65,APOA1,NF1,APOA2 |
| cytoskeletal protein binding | PACSIN3,PTPN3,PACSIN1A,MSNB,EPB41L3A,FARP1,TPM1,CDK5,SLC8A1,TOR1A |
| fructose binding | PFKL,ALDOA,PFKM |
Interacting Protein
ALDOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDOB here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDOB.
BBS7;BBS1;BBS4;BBS2;Slc12a1;HUS1;BUB1
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