ALAS1

  • Official Full Name

    aminolevulinate, delta-, synthase 1

  • Overview

    Delta-aminolevulinate synthase (ALAS; EC 2.3.1.37) catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2 (MIM 301300).

  • Synonyms

    ALAS1;aminolevulinate, delta-, synthase 1;ALAS, ALAS3;5-aminolevulinate synthase, nonspecific, mitochondrial;mitochondrial;nonspecific;5 aminolevulinate synthase;5 aminolevulinate synthase nonspecific mitochondrial;5 aminolevulinic acid synthase;5-aminolevulinate synthase;5-aminolevulinic acid synthase 1;Alas 1;ALAS 3;ALAS;ALAS H;ALAS HOUSEKEEPING TYPE;ALAS N;ALAS-H;ALAS3;ALASH;Aminolevulinate delta synthase 1;Aminolevulinic acid synthase 1;Delta ALA synthetase;Delta aminolevulinate synthase;Delta-ALA synthase 1;Delta-aminolevulinate synthase 1;HEM1_HUMAN;MIG 4;MIG4;Migration inducing protein 4;OTTHUMP00000212619;OTTHUMP00000212620;OTTHUMP00000212621;OTTHUMP00000212622;migration-inducing protein 4

Recombinant Proteins

  • Zebrafish
  • Chicken
  • Human
  • Rat
  • Mouse
  • Mammalian Cell
  • E.coli
  • Wheat Germ
  • HEK293
  • E. coli
  • His
  • GST
  • Non
  • N-His
  • His&GST
  • His&Fc&Avi
  • His&Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ALAS1-11435Z Recombinant Zebrafish ALAS1 Mammalian Cell Zebrafish His
ALAS1-2179C Recombinant Chicken ALAS1 Mammalian Cell Chicken His
ALAS1-311H Recombinant Human ALAS1 Protein, His-tagged E.coli Human His
ALAS1-312H Recombinant Human ALAS1 Protein, His-tagged E.coli Human His
ALAS1-429H Recombinant Human ALAS1 Protein, GST-tagged Wheat Germ Human GST
ALAS1-610R Recombinant Rat ALAS1 Protein Mammalian Cell Rat His
ALAS1-8924HCL Recombinant Human ALAS1 293 Cell Lysate HEK293 Human Non
ALAS1-8925HCL Recombinant Human ALAS1 293 Cell Lysate HEK293 Human Non
ACSL3-3787H Recombinant Human ACSL3 protein, His-tagged E. coli Human N-His 42-160 aa
Alas1-111R Recombinant Rat Alas1 Protein, His&GST-tagged E.coli Rat His&GST Lys355-Ala642
ALAS1-266R Recombinant Rat ALAS1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ALAS1-266R-B Recombinant Rat ALAS1 Protein Pre-coupled Magnetic Beads HEK293 Rat
ALAS1-26883TH Recombinant Human ALAS1 Wheat Germ Human Non 98 amino acids
Alas1-4696M Recombinant Mouse Alas1 protein, His&Myc-tagged E.coli Mouse His&Myc 57-642aa

    Involved Pathway

    ALAS1 involved in several pathways and played different roles in them. We selected most pathways ALAS1 participated on our site, such as Glycine, serine and threonine metabolism,Porphyrin and chlorophyll metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycine, serine and threonine metabolism PIPOX,CTH,AGXTA,PGAM1B,CBS,PGAM1,DLDH,SDSL,PGAM1A,MAOB
    Porphyrin and chlorophyll metabolism HCCSB,P22,HCCS,FECH,UGT1A7C,UGT1AB,HMOX1A,UGT2A1,UGT1A6A,UGT1A1
    Metabolic pathways QARS,B3GNT5A,MTHFD1L,LCT,DHDPSL,POLR1C,ITGB1BP3,ARG1,RPN1,NAT1

    Protein Function

    ALAS1 has several biochemical functions, for example, 5-aminolevulinate synthase activity,protein binding,pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALAS1 itself. We selected most functions ALAS1 had, and list some proteins which have the same functions with ALAS1. You can find most of the proteins on our site.

    Function Related Protein
    pyridoxal phosphate binding PROSC,ABAT,SPTLC2A,AGXT2L1,AGXT2L2,GAD1B,CSAD,SDS,PYGL,SPTLC2
    protein binding GATC,BRIP1,ANKRD1,EIF4G2,FCHO2,CHMP4B,ATG12,DOK2,LARP7,DNAJB2
    5-aminolevulinate synthase activity ALAS2

    Interacting Protein

    ALAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALAS1.

    DUSP19;EP400;POLDIP2;7115

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