AKAP12
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Official Full Name
A kinase (PRKA) anchor protein 12 -
Overview
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
AKAP12;A kinase (PRKA) anchor protein 12;SSeCKS;AKAP250;A-kinase anchor protein 12;AKAP 250;kinase scaffold protein gravin;A-kinase anchor protein, 250kDa;Src-Suppressed C Kinase Substrate;myasthenia gravis autoantigen gravin
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AKAP12-8983H | Recombinant Human AKAP12 protein, His-tagged | E.coli | Human | His | Pro1485~Ser1782 | |
| AKAP12-287R | Recombinant Rhesus monkey AKAP12 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| AKAP12-398H | Recombinant Human AKAP12 Protein, GST-tagged | Wheat Germ | Human | GST |
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| AKAP12-588R | Recombinant Rat AKAP12 Protein | Mammalian Cell | Rat | His |
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| AKAP12-8941HCL | Recombinant Human AKAP12 293 Cell Lysate | HEK293 | Human | Non |
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| AKAP12-115R | Recombinant Rhesus Macaque AKAP12 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| AKAP12-115R-B | Recombinant Rhesus Macaque AKAP12 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| AKAP12-244R | Recombinant Rat AKAP12 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| AKAP12-244R-B | Recombinant Rat AKAP12 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| AKAP12-2822H | Recombinant Human AKAP12 protein(421-530 aa), C-His-tagged | E.coli | Human | His | 421-530 aa |
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Involved Pathway
AKAP12 involved in several pathways and played different roles in them. We selected most pathways AKAP12 participated on our site, such as G Protein Signaling Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G Protein Signaling Pathways | AKAP6,AKAP10,Akap3,GNB3B,AKAP12B,ARHGEF1A,AKAP13,AKAP1,GNGT2A,GNG13B |
Protein Function
AKAP12 has several biochemical functions, for example, adenylate cyclase binding,protein binding,protein kinase A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP12 itself. We selected most functions AKAP12 had, and list some proteins which have the same functions with AKAP12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SOX4,FNTB,VSNL1,NUMBL,GNB1,NIF3L1,TGFA,EPN3,TMEM74,RPL9 |
| adenylate cyclase binding | ADCYAP1R1,ADRB2,CALM3,CALM2,CALM1,CHRNA7,AKAP6,AKAP5 |
| protein kinase A binding | DACT2,AKAP13,AKAP17A,LRRK2,Akap3,AKAP5,DACT3,Akap2,AKAP7,NBEA |
Interacting Protein
AKAP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP12.
FHL1;EGFR;PRKAR2A;CTNNB1;PDE4D;Akap12;yknZ
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