AIFM2
-
Official Full Name
apoptosis-inducing factor, mitochondrion-associated, 2 -
Overview
This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. -
Synonyms
AIFM2;apoptosis-inducing factor, mitochondrion-associated, 2;AMID, apoptosis inducing factor (AIF) like mitochondrion associated inducer of death;apoptosis-inducing factor 2;FLJ14497;PRG3;5430437E11Rik;AIFM2_HUMAN;AMID;Apoptosis inducing factor (AIF) homologous mitochondrion associated inducer of death;Apoptosis inducing factor (AIF) like mitochondrion associated inducer of death;Apoptosis inducing factor mitochondrion associated 2;Apoptosis-inducing factor homologous mitochondrion-associated inducer of death;Apoptosis-inducing factor-like mitochondrion-associated inducer of death;Cys51Stop;HGNC11998;p53 responsive gene 3;p53 tumor suppressor;p53-responsive gene 3 protein;TRP53;Tumor protein p53;OTTHUMP00000019739;OTTHUMP00000019740;apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death;apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of d;RP11-367H5.2
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Xenopus laevis
- Bovine
- Taeniopygia guttata (Zebra finch) (Poephila guttata)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
AIFM2 involved in several pathways and played different roles in them. We selected most pathways AIFM2 participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with AIFM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Direct p53 effectors | DDX5,CSE1L,CTSD,FOXA1,DUSP1,FDXR,BCL2L14,TRIAP1,CD82,PCBP4 |
Protein Function
AIFM2 has several biochemical functions, for example, DNA binding,electron-transferring-flavoprotein dehydrogenase activity,flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AIFM2 itself. We selected most functions AIFM2 had, and list some proteins which have the same functions with AIFM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF280D,ZFP354C,ADAR,PAX3A,ZNF593,CHD2,OLIG1,UNCX,TDP2B,IRX5A |
| flavin adenine dinucleotide binding | ACADM,SQLE,ACAD9,CYBB,GCDH,ACADVL,TXNRD2,MAOA,D2HGDH,DUS1L |
| electron-transferring-flavoprotein dehydrogenase activity | ETFDH |
Interacting Protein
AIFM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIFM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIFM2.
MYC;USE1
Resources
Related Services
Related Products
References
