AHRR
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Official Full Name
aryl-hydrocarbon receptor repressor -
Overview
The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
AHRR;aryl-hydrocarbon receptor repressor;AHH, AHHR, aryl hydrocarbon receptor regulator;aryl hydrocarbon receptor repressor;bHLHe77;KIAA1234;AHH;AhR repressor;AHRR_HUMAN;aryl hydrocarbon hydroxylase regulator;aryl hydrocarbon receptor regulator;Arylhydrocarbon receptor repressor;Class E basic helix-loop-helix protein 77;Dioxin receptor repressor;MGC167813;MGC176630;OTTHUMP00000221488;OTTHUMP00000221489;AHHR
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rat
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AHRR-1444M | Recombinant Mouse AHRR Protein | Mammalian Cell | Mouse | His |
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| AHRR-3649H | Recombinant Human AHRR, His-tagged | E.Coli or Yeast | Human | His | 701 |
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| AHRR-4485C | Recombinant Chicken AHRR | Mammalian Cell | Chicken | His |
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| AHRR-465H | Recombinant Human AHRR Protein, GST-tagged | Wheat Germ | Human | GST |
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| AHRR-466H | Recombinant Human AHSA1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| AHRR-573R | Recombinant Rat AHRR Protein | Mammalian Cell | Rat | His |
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| AHRR-1698H | Recombinant Human AHRR protein, His & GST-tagged | E.coli | Human | His&GST | Met1~Pro182 |
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| AHRR-229R | Recombinant Rat AHRR Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| AHRR-229R-B | Recombinant Rat AHRR Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| AHRR-406M | Recombinant Mouse AHRR Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| AHRR-406M-B | Recombinant Mouse AHRR Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| AHRR-950HF | Recombinant Full Length Human AHRR Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 719 amino acids |
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Involved Pathway
AHRR involved in several pathways and played different roles in them. We selected most pathways AHRR participated on our site, such as AhR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHRR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AhR pathway | CYP1A2,CYP1A1,CDKN1A,JUN,PTGES3,CDC37,NQO1,CYP1B1,AHR,AIP |
Protein Function
AHRR has several biochemical functions, for example, DNA binding,protein dimerization activity,transcriptional repressor activity, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHRR itself. We selected most functions AHRR had, and list some proteins which have the same functions with AHRR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF705B,MEF2C,NR1I3,RUNX1T1,ZFP260,SIX1A,ZFP512,TEAD2,ORC4,HOXA11B |
| transcriptional repressor activity, RNA polymerase II transcription factor binding | MINA,BHLHE40,AHRRB,AHRRA,MLIP,TBX6,ELP2,RIMKLB,EOMES,CREBBP |
| protein dimerization activity | SRFA,ASCL1A,MYO5A,HIF1AL,ANO7,GPR139,NCF4,SMG1,NPAS4,EBF3A |
Interacting Protein
AHRR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHRR here. Most of them are supplied by our site. Hope this information will be useful for your research of AHRR.
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References
- Basham, KJ; Leonard, CJ; et al. Dioxin Exposure Blocks Lactation through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor. TOXICOLOGICAL SCIENCES 143:36-45(2015).
- Merson, RR; Franks, DG; et al. Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 142:85-94(2006).
