AHR
-
Official Full Name
aryl hydrocarbon receptor -
Overview
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. -
Synonyms
AHR;aryl hydrocarbon receptor;bHLHe76;AH-receptor;ah receptor;aromatic hydrocarbon receptor;class E basic helix-loop-helix protein 76
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Sf9 Cells
- Mammalian Cells
- Wheat Germ
- E.Coli/Yeast
- HEK293
- In Vitro Cell Free System
- His
- GST
- GST&His
- Non
- Avi&Fc&His
Involved Pathway
AHR involved in several pathways and played different roles in them. We selected most pathways AHR participated on our site, such as Adipogenesis,AhR pathway,Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AhR pathway | CYP1B1,JUND,CDKN1A,CDC37,AHRR,JUN,NQO1,AIP,PTGES3,CYP1A1 |
| Adipogenesis | KLF5,NR2F1,NAMPT,STIL,AGPAT2,BMP3,SMAD3B,NR1H3,GADD45A,GATA2A |
| Integrated Breast Cancer Pathway | GRN,RPP38,DCAKD,CYP19A1,SELK,ZMIZ1,GDI1,NAB1,ERAL1,UBE2F |
Protein Function
AHR has several biochemical functions, for example, DNA binding,E-box binding,Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHR itself. We selected most functions AHR had, and list some proteins which have the same functions with AHR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | SMC2,PIK3R2,ERBB2,UGT1A4,TWIST1,MAFA,ADD1,TP53,MEF2A,TBX18 |
| E-box binding | NEUROG2,ASCL2,TWIST1,MYOG,MYOD1,MYC,ARNTL,ATOH8,ZEB1,TAL1 |
| enhancer binding | LEF1,SMAD3,SP1,ARNT,SOX9,TCF12,RAI1,TIPARP,TCF3,MESP1 |
| transcription factor binding | DRG1,YWHAZ,HMGA1-RS1,NKX2,INSIG2,MAFB,BCL10,NFATC4,E2F4,HEY1 |
| DNA binding | SP2,FOXF2,ZZZ3,SRRT,EPAS1B,SERPINA3,ZNF207,RNF11,TFCP2,SCXB |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | VDRA,NR5A1,AHR2,Ar,ESRRB,NR1H4,RORA,NR4A2A,NR2F1A,NR5A1A |
| protein binding | C10orf28,RBL1,SPSB4,GGT1,FAM164A,NPRL2,C19orf40,LPAL2,GTF2E2,TUBGCP4 |
| Hsp90 protein binding | PPID,RPS3,ERN1,STUB1,HDAC6,GBP1,CSNK2A1,NPAS2,UNC45A,HIF1A |
| sequence-specific DNA binding | PAX7,GLI2,DLX2A,HOXB13A,LHX2B,LMX1B,NFE2L1A,NR1D2A,NKX2.4A,NR2F1 |
Interacting Protein
AHR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHR here. Most of them are supplied by our site. Hope this information will be useful for your research of AHR.
EBNA3;ARNT;NCOA7;NCOR2;AIP;MAF;RB1
Resources
Research Area
Transcription Regulators in VSMCTranscription Factors in the Akt Pathway
Hematopoietic Stem Cell Transcription Factors and Regulators
Th22 Cells
Related Services
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References
- Kim, JY; Sohn, JH; et al. Obesity Increases Airway Hyperresponsiveness via the TNF-alpha Pathway and Treating Obesity Induces Recovery. PLOS ONE 10:-(2015).
