AGTRAP
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Official Full Name
angiotensin II receptor-associated protein -
Overview
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. -
Synonyms
AGTRAP;angiotensin II receptor-associated protein;type-1 angiotensin II receptor-associated protein;ATRAP;AT1 receptor-associated protein;ATI receptor-associated protein;angiotensin II, type I receptor-associated protein;MGC29646
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Pongo Abelii
- Mus musculus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In vitro E. coli expression system
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- His&Myc&SUMO
- His&GST
- His&Myc
Involved Pathway
AGTRAP involved in several pathways and played different roles in them. We selected most pathways AGTRAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AGTRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AGTRAP has several biochemical functions, for example, angiotensin type II receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGTRAP itself. We selected most functions AGTRAP had, and list some proteins which have the same functions with AGTRAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GSE1,ERBB3,ETV7,ZNF350,PABPC1,KRT8,RADIL,ECHS1,KIF2A,NPHS1 |
| angiotensin type II receptor activity | AGTR1,CXCR3.2,APLNRB,AGTR2,RXFP3.2B,AGTR1A,RXFP4,APLNRA,AGTR1B |
Interacting Protein
AGTRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGTRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of AGTRAP.
PITPNC1;PDHX;PTPN9;ARFIP2;SPG21
Resources
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References
- Gomes, I; Gupta, A; et al. G-Protein-Coupled Heteromers: Regulation in Disease. G PROTEIN COUPLED RECEPTORS: TRAFFICKING AND OLIGOMERIZATION 521:219-238(2013).
- Gu, J; Liu, X; et al. Angiotensin II increases CTGF expression via MAPKs/TGF-beta 1/TRAF6 pathway in atrial fibroblasts. EXPERIMENTAL CELL RESEARCH 318:2105-2115(2012).
