AGRP
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Official Full Name
agouti related protein homolog (mouse) -
Overview
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. -
Synonyms
AGRP;agouti related protein homolog (mouse);agouti (mouse) related protein;agouti-related protein;Agrt;ART;ASIP2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- HEK293
- Sf21 Insect Cell
- E.coli
- Mammalian Cell
- Human Cell
- E. coli
- HEK293T
- HEK293F
- His
- Fc
- Non
- mFc
- Myc&DDK
- N-His
- His&SUMO
- GST
Involved Pathway
AGRP involved in several pathways and played different roles in them. We selected most pathways AGRP participated on our site, such as Adipocytokine signaling pathway,Syndecan-3-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGRP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Syndecan-3-mediated signaling events | COL20A1,PTN |
| Adipocytokine signaling pathway | NFKBIAA,CPT1C,IRS4,ACSL4A,PRKAA1,STK11,PRKAA2,POMC,AKT2,TRADD |
Protein Function
AGRP has several biochemical functions, for example, neuropeptide hormone activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGRP itself. We selected most functions AGRP had, and list some proteins which have the same functions with AGRP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | FGF1A,CSNK2B,VTCN1,TNFSF9,TDGF1,FGF20B,NRG2,IL29,Fert2,JAK2 |
| neuropeptide hormone activity | NPY,CCK,CORT,CRH,PNOC,CALCB,TRH,GRP,GAL,VIP |
Interacting Protein
AGRP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGRP here. Most of them are supplied by our site. Hope this information will be useful for your research of AGRP.
Resources
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References
- Lei, MM; Wu, SQ; et al. Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. DOMESTIC ANIMAL ENDOCRINOLOGY 50:55-64(2015).
- Lelliott, CJ; Ahnmark, A; et al. Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms. PLOS ONE 9:-(2014).
