AES
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Official Full Name
amino-terminal enhancer of split -
Overview
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
AES;amino-terminal enhancer of split;GRG;ESP1;GRG5;TLE5;AES-1;AES-2;gp130-associated protein GAM
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Cynomolgus
- Rat
- Mammalian Cell
- E.coli
- E.Coli or Yeast
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
AES involved in several pathways and played different roles in them. We selected most pathways AES participated on our site, such as Androgen receptor signaling pathway,Degradation of beta-catenin by the destruction complex,Presenilin action in Notch and Wnt signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Repression of WNT target genes | TLE3B,TLE3,TLE2,TLE4 |
| Androgen receptor signaling pathway | RANBP9,CDKN1A,RNF14,CTNNB2,KAT7,CTNNB1,DAXX,PSMC3IP,ZMIZ1,POU2F1B |
| Presenilin action in Notch and Wnt signaling | WIF1,KREMEN2,TLE1 |
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | CBY1,CDX1,MYOG,TLE1,CYR61,KCNIP4,SALL4,IGF2BP1,BCL9,TCF4 |
| Signaling by Wnt | PYGO2,ROR1,RSPO2,GPR177,LEO1,SOX9A,SOX6,RYK,RNF43,ROR2 |
| Signal Transduction | RGS1,WDR35,FSTL1B,IQGAP3,ARHGEF18A,AMOTL2B,ZFPM2B,PPEF1,WWOX,GPR120 |
| Degradation of beta-catenin by the destruction complex | FAM123B,TLE2,CTBP1,CTBP2,TLE4,TLE1,TLE3,TLE3B |
Protein Function
AES has several biochemical functions, for example, protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AES itself. We selected most functions AES had, and list some proteins which have the same functions with AES. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | APEX1,C1D,ID4,SP100,CBFA2T3,NR0B2A,CTBP2A,ANKRD1,AEBP2,KCNIP3 |
| protein binding | DDX6,IGF2R,CHMP6,PPID,BIN3,FAM129A,EDC3,RAB8B,SSX2IP,OFD1 |
Interacting Protein
AES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AES here. Most of them are supplied by our site. Hope this information will be useful for your research of AES.
PTRH2;KRT13;FSD2;VPS37C;ARHGAP32;386682
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References
- Zhou, XL; Wang, JM; et al. Symptoms and toxicity of rituximab maintenance relative to observation following immunochemotherapy in patients with follicular lymphoma. HEMATOLOGY 20:129-136(2015).
- Krishnan, A; Stobaugh, DJ; et al. Assessing the likelihood of new-onset inflammatory bowel disease following tumor necrosis factor-alpha inhibitor therapy for rheumatoid arthritis and juvenile rheumatoid arthritis. RHEUMATOLOGY INTERNATIONAL 35:661-668(2015).
