ADRBK2
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Official Full Name
adrenergic, beta, receptor kinase 2 -
Overview
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and;related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with;beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest;the existence of a family of receptor kinases which may serve broadly to regulate receptor function. -
Synonyms
ADRBK2;adrenergic, beta, receptor kinase 2;beta-adrenergic receptor kinase 2;BARK2;GRK3;beta-ARK-2;G-protein-coupled receptor kinase 3
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Insect Cells
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- Sf21 Cells
- In Vitro Cell Free System
- GST
- His
- Non
- Avi&Fc&His
Involved Pathway
ADRBK2 involved in several pathways and played different roles in them. We selected most pathways ADRBK2 participated on our site, such as Chemokine signaling pathway,Corticotropin-releasing hormone,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRBK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | GRM4,GNAS,GNG13,GNG8,GRIA1,SLC38A3,GRM3,HOMER2,PPP3CC,PLCB4 |
| Thromboxane A2 receptor signaling | ARR3,SLC9A3R1 |
| Chemokine signaling pathway | RAC2,CXCR2,GRK1,CCL3L1,XCR1,GNAI2,CCL11,STAT5B,PTK2B,CX3CL1 |
| Corticotropin-releasing hormone | CRH,TBX19,CRHR1,JUNB,TFAP2A,CRHR2,JUND,CASP12,KRT1,IVL |
| Endocytosis | RAB11FIP4,GRK1,KITB,EHD1A,IGF1RA,CYTH1B,RAB31,TRAF6,HLA-A,AGAP1 |
| Olfactory transduction | OR2J3,OLFR998,OLFR493,OR2AP1,OLFR469,CLCA1,CALML3,OR52B6,OLFR151,OR51B5 |
| IL-4 signaling Pathway | DOK2,PAWR,IL4R.1,HMGA1-RS1,SPI1B |
Protein Function
ADRBK2 has several biochemical functions, for example, ATP binding,G-protein coupled receptor kinase activity,beta-adrenergic receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRBK2 itself. We selected most functions ADRBK2 had, and list some proteins which have the same functions with ADRBK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NEK1,LIMK1A,FGFR1B,TIE1,MYHZ2,UBA5,DNAH11,PAPOLA,ACSL5,BBS10 |
| G-protein coupled receptor kinase activity | GRK7B,GRK7A,GRK7,GRK1,RLN1,GRK6,GRK1A,GRK4,GRK5,GRK1B |
| beta-adrenergic receptor kinase activity | GRK5,ADRBK1,GRK6 |
| protein kinase activity | FGFR1B,DYRK1B,MMD2,CDK14,PTK2,TRIO,DCKL1B,BMPR2B,MAP3K1,STK24 |
Interacting Protein
ADRBK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRBK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRBK2.
Opn4;HSPB1;groL;15-deoxy-delta(12,14;ADRBK1
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References
- Wex, E; Thaler, E; et al. A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats. PLOS ONE 9:-(2014).
- Rahbek-Clemmensen, T; Bay, T; et al. The Serotonin Transporter Undergoes Constitutive Internalization and Is Primarily Sorted to Late Endosomes and Lysosomal Degradation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:23004-23019(2014).
