ADIPOR2
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Official Full Name
Adiponectin Receptor 2 -
Overview
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length;adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand;activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 (PubMed;12802337)). -
Synonyms
ADIPOR2;adiponectin receptor 2;PAQR2;ACDCR2;adiponectin receptor protein 2;progestin and adipoQ receptor family member II;FLJ21432;MGC4640;OTTHUMP00000160634
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Rat
- Mus musculus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- His&GST
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
ADIPOR2 involved in several pathways and played different roles in them. We selected most pathways ADIPOR2 participated on our site, such as AMPK signaling pathway,Adipocytokine signaling pathway,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with ADIPOR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | PIK3R3,NDUFV1,NDUFB8,IL-8,LEP,NDUFB1,UQCRC1,KCNA3,COX7B,NDUFV3 |
| AMPK signaling pathway | RAB8A,CPT1A,PIK3CG,PPP2R3A,HNF4A,CCNA2,SCD,GYS1,ELAVL1,PIK3R5 |
| Adipocytokine signaling pathway | SOCS3,JAK2B,MAPK8A,LEPR,ADIPOQB,PTPN11A,G6PC2,ACSBG1,ACSL1A,IKBKB |
Protein Function
ADIPOR2 has several biochemical functions, for example, adipokinetic hormone receptor activity,adiponectin binding,hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADIPOR2 itself. We selected most functions ADIPOR2 had, and list some proteins which have the same functions with ADIPOR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adipokinetic hormone receptor activity | ADIPOR1 |
| receptor activity | ITGB4,CD93,GRIA4A,GABRA5,F2RL1.2,KIR2DL3,CD226,PVRL2L,LILRA2,ITGB3A |
| hormone binding | LRP2,AMHR2,MC5R,MTNR1A,CALR,MC1R,NPR1,ADIPOR1A,TTR,CRYM |
| protein heterodimerization activity | Defa-rs7,UGT1A3,HIST1H4K,KATNB1,SRY,DMRT3,NR4A2,SOX32,TAF12,BAXB |
| identical protein binding | VWF,P2RX6,ALCAMB,SIAH1A,PCBD1,CLDN7,HSP90AA1,NCAM1,HACL1,PSMA7 |
| metal ion binding | AMPD1,PDSS1,METAP2A,ROCK2B,RUFY2,ZNF672,U2AF1L4,FREM2,ZNFL2A,DYTN |
| adiponectin binding | ADIPOR1,CDH13 |
Interacting Protein
ADIPOR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADIPOR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADIPOR2.
APPL1
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References
- Ramachandran, R; Maddineni, S; et al. Expression of adiponectin and its receptors in avian species. GENERAL AND COMPARATIVE ENDOCRINOLOGY 190:88-95(2013).
- Su, YC; Xiang, RL; et al. Decreased submandibular adiponectin is involved in the progression of autoimmune sialoadenitis in non-obese diabetic mice. ORAL DISEASES 20:744-755(2014).
